[非甾体抗炎药所致荨麻疹：治疗方法与急性荨麻疹相似]

[NSAID urticaria: Similar management to acute urticaria].

作者信息

Khandzian M, Hacard F, Braire-Bourrel M, Jaulent C, Bérard F, Nicolas J-F, Nosbaum A

机构信息

Service d'allergologie et immunologie clinique, hospices civils de Lyon, CHU Lyon-Sud, 69495 Pierre Bénite cedex, France; Université Lyon I, 69007 Lyon, France.

Service d'allergologie et immunologie clinique, hospices civils de Lyon, CHU Lyon-Sud, 69495 Pierre Bénite cedex, France; - CIRI, Centre International de Recherche en Infectiologie, équipe 14, Univ Lyon, Inserm, U111, université Claude-Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France.

出版信息

Rev Med Interne. 2019 Mar;40(3):166-172. doi: 10.1016/j.revmed.2018.12.008. Epub 2019 Jan 7.

DOI:10.1016/j.revmed.2018.12.008

PMID:30630637

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common providers of immediate hypersensitivity reactions. Among these reactions, isolated acute urticaria is the most common clinical feature with a non-allergic origin. It is a pharmacological side effect resulting from the alteration of arachidonic acid metabolism induced by NSAIDs. Diagnosis of this acute urticaria is clinical, requiring no allergy testing. Currently, the recommended therapeutic management of NSAID urticaria is the avoidance of all NSAID with COX-1 inhibitor activity (even if when reintroduced, they are most often well tolerated) and the use of selective COX-2 inhibitors. This review focuses on urticaria reactions to NSAIDs, which are simple to manage.

摘要

非甾体抗炎药（NSAIDs）是引起速发型超敏反应最常见的药物。在这些反应中，孤立性急性荨麻疹是最常见的非过敏性起源的临床特征。它是由NSAIDs诱导的花生四烯酸代谢改变所导致的一种药理学副作用。这种急性荨麻疹的诊断依靠临床诊断，无需进行过敏测试。目前，对于NSAIDs荨麻疹推荐的治疗管理方法是避免使用所有具有COX-1抑制剂活性的NSAIDs（即使再次使用时，它们大多耐受性良好），并使用选择性COX-2抑制剂。本综述重点关注对NSAIDs的荨麻疹反应，这类反应易于处理。