Yu Bo, Chen Xiangxiu, Jiang Lingling, Shang Yishun, Song Xu, Zhou Sixuan, Xu Jinge, Yu Jiankang, Fu Qiuting, Peng Shuwei, Liu Songtao, Yang Yueqian, Yin Zhongqiong
Institute of Animal Husbandry and Veterinary Medicine of GAAS, Guiyang, Guizhou China.
Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Pak J Pharm Sci. 2018 Nov;31(6(Special)):2855-2862.
"Shikuqin" (SKQ) powder consists of three Chinese herbs: Punica granatum L, Sophora flavescens Ait, and Fraxinus rhynchophylla Hance. SKQ has been used for the treatment of diarrhea. In order to provide a comprehensive understanding of toxicity, the acute and sub-chronic toxicity and safety pharmacology of SKQ were evaluated in the present study. The result of the acute toxicity revealed that the LD50 of the valve was 28,379mg/kg.b.w, which was more than 5,000 mg/kg b.w. The 30-day sub-chronic toxicity test results revealed that compared with the control group, the clinical signs, hematology parameters and body weight of rats in each group had no significant differences. The viscera coefficient and histopathological examination results revealed that the SKQ powder could cause kidney and liver damage. In the safety pharmacology test, SKQ did not exhibit any toxicity to the central nervous system, cardiovascular system and respiratory system. In conclusion, SKQ powder could be considered safe for veterinary use.
“十苦参”（SKQ）散由三种中药材组成：石榴皮、苦参和秦皮。SKQ已被用于治疗腹泻。为全面了解其毒性，本研究对SKQ进行了急性和亚慢性毒性及安全药理学评价。急性毒性结果显示，其半数致死量（LD50）为28379mg/kg体重，超过5000mg/kg体重。30天亚慢性毒性试验结果显示，与对照组相比，各组大鼠的临床体征、血液学参数和体重均无显著差异。脏器系数和组织病理学检查结果显示，SKQ散可导致肾脏和肝脏损伤。在安全药理学试验中，SKQ对中枢神经系统、心血管系统和呼吸系统均未表现出任何毒性。综上所述，SKQ散可被认为用于兽医领域是安全的。
