Suryaprasanna Jammula, Radhika Potini Lakshmi, Karunakar Parupalli, Rekharani Koduganti, Faizuddin Umrana, Manojkumar Mallela George, Jammula Suribabu
Department of Periodontics, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.
Department of Conservative and Endodontics, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.
J Indian Soc Periodontol. 2018 Nov-Dec;22(6):529-534. doi: 10.4103/jisp.jisp_254_18.
Administration of systemic antibiotics may implement persuasive treatment effect for chronic periodontitis by intending tissue-invasive bacteria in addition to accustomed nonsurgical periodontal therapy (NSPT).
The aim of this study was to assess the ancillary effects of oral clarithromycin (CLM) along with NSPT for chronic periodontitis.
Thirty periodontitis patients were randomly divided into two equal groups in this double-blind, randomized, parallel group, and active-controlled trial: test group - scaling and root planning (SRP) plus CLM (500 mg thrice daily for 7 days, orally) was given, and control group - only SRP was done. Clinical analysis, such as gingival index (GI), probing depth (PD), and clinical attachment loss (CAL), were taken at baseline, 3 months, and 6-month intervals for both groups. Subgingival plaque samples were cultured for periodontopathic organisms. Immunological parameter C-reactive protein (CRP) levels were estimated.
SPSS version 14 was used for statistical analysis. The intragroup comparison showed a significant reduction in the mean scores of all the parameters from baseline to 6 months. The intergroup comparison showed a statistically significant reduction of PD from baseline to 3 months ( < 0.001). GI, CAL, and CRP levels were also reduced but not statistically significant. The mean colony-forming units (CFU) of (Aa) and (Pg) showed a statistically significant reduction from baseline to 3 months only in the test group ( = 0.042) and ( = 0.046), respectively. There was no statistically significant reduction of Aa and Pg at 6 months.
CLM conceivably accepted as an addendum to NSPT for a shorter period.
除了常规的非手术牙周治疗（NSPT）外，全身应用抗生素可能通过针对组织侵袭性细菌对慢性牙周炎产生显著的治疗效果。
本研究的目的是评估口服克拉霉素（CLM）联合NSPT治疗慢性牙周炎的辅助效果。
在这项双盲、随机、平行组、活性对照试验中，30例牙周炎患者被随机分为两组，每组人数相等：试验组——进行龈上洁治和根面平整（SRP）并口服CLM（500mg，每日3次，共7天），对照组——仅进行SRP。两组在基线、3个月和6个月时进行临床分析，如牙龈指数（GI）、探诊深度（PD）和临床附着丧失（CAL）。对龈下菌斑样本进行牙周病原菌培养。评估免疫参数C反应蛋白（CRP）水平。
使用SPSS 14版进行统计分析。组内比较显示，从基线到6个月，所有参数的平均得分均显著降低。组间比较显示，从基线到3个月，PD有统计学意义的降低（<0.001）。GI、CAL和CRP水平也有所降低，但无统计学意义。仅在试验组中，伴放线聚集杆菌（Aa）和牙龈卟啉单胞菌（Pg）的平均菌落形成单位（CFU）从基线到3个月有统计学意义的降低，分别为（=0.042）和（=0.046）。6个月时Aa和Pg无统计学意义的降低。
CLM可在较短时间内被认为是NSPT的补充治疗。
