Hammami Chaima, Nasri Wafa
University of Monastir, Dental Medecine Faculty of Monastir, Periodontal Departement, Oral Health and Oral Rehabilitation Research Laboratory, LR12ES11, Monastir 5019, Tunisia.
Int J Dent. 2021 Nov 8;2021:6846074. doi: 10.1155/2021/6846074. eCollection 2021.
Systemic antibiotics present one of the alternative adjunctive therapies in nonsurgical periodontal treatment (NSPT). Different protocols have been proposed, but their indication and effectiveness are still controversial. The aim of this study is to assess the effectiveness of the addition of antibiotics after nonsurgical debridement during initial therapy and compare different antimicrobial prescription protocols.
An electronic search was performed through MEDLINE and EBSCOhost databases using the appropriate MeSH words. The target studies have to be published during the last five years. Data from the selected studies were extracted and analyzed. Study selection was done based on inclusion and exclusion criteria.
Seven randomized clinical trials were included in our review. Their data were extracted using a grid established for this purpose. Collectively, different protocols have been proposed and almost all of them yield superior clinical and microbiological results compared to the placebo group.
The overall findings of this review show a positive effect of the use of antibiotics as an adjunctive to NSPT, regardless of the antimicrobial agents used in our included studies. Sites with PD > 6 mm may benefit most from the adjunctive use of antibiotics in NSPT. This trial is registered with Clinicaltrials.gov identifiers: NCT02829983 (Bechara Andere et al., 2016); NCT02839421 (Ardila et al., 2020); NCT02735395 (Borges et al., 2017); NCT02359721 (Suryaprasanna et al., 2018); and NCT01318928 (Hans, 2015).
全身用抗生素是非手术牙周治疗（NSPT）中的一种替代辅助治疗方法。已经提出了不同的方案，但其适应证和有效性仍存在争议。本研究的目的是评估初始治疗期间非手术清创后添加抗生素的有效性，并比较不同的抗菌药物处方方案。
通过MEDLINE和EBSCOhost数据库，使用适当的医学主题词进行电子检索。目标研究必须在过去五年内发表。提取并分析所选研究的数据。根据纳入和排除标准进行研究选择。
我们的综述纳入了七项随机临床试验。使用为此目的建立的表格提取了它们的数据。总体而言，已经提出了不同的方案，与安慰剂组相比，几乎所有方案都产生了更好的临床和微生物学结果。
本综述的总体结果表明，无论我们纳入的研究中使用何种抗菌药物，使用抗生素作为NSPT的辅助治疗都有积极效果。在NSPT中，牙周袋深度（PD）>6mm的部位可能最受益于抗生素的辅助使用。本试验已在Clinicaltrials.gov注册，标识符为：NCT02829983（贝查拉·安德雷等人，2016年）；NCT02839421（阿尔迪拉等人，2020年）；NCT02735395（博尔热斯等人，2017年）；NCT02359721（苏里亚普拉桑纳等人，2018年）；以及NCT01318928（汉斯，2015年）。
