Chang Ya-Qin, Fang Fang-Fang, Qin Sha-Sha, Dong Ying-Chun, Chen Bin
Dept. of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Dept. of Non-Communicable Diseases Prevention and Control, Xi'an Center for Disease Control and Prevention, Xi'an 710054, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Aug 1;38(4):385-392. doi: 10.7518/hxkq.2020.04.006.
To evaluate the effect of scaling and root planing (SRP) on serum C-reactive protein (CRP) levels in patients with moderate to severe chronic periodontitis.
We searched the PubMed, Web of Science, EMBASE, Cochrane, CNKI, Wanfang, and VIP databases from the inception to July 8th, 2019. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Then, a meta-analysis was performed using RevMan 5.3 software.
A total of 13 randomized controlled clinical trials and 12 prospective clinical trials were included. Meta-analysis showed that serum CRP levels decreased at 2 and 3 months after SRP (P<0.05), and no significant difference in serum CRP levels was found at 6 months (P=0.49).
SRP can reduce serum CRP levels in systematically healthy patients with moderate to severe chronic periodontitis at 2 and 3 months after SRP.
评估龈下刮治和根面平整术（SRP）对中重度慢性牙周炎患者血清C反应蛋白（CRP）水平的影响。
检索PubMed、Web of Science、EMBASE、Cochrane、中国知网、万方和维普数据库，检索时间从建库至2019年7月8日。两名研究者独立筛选文献、提取数据并评估纳入研究的偏倚风险。然后，使用RevMan 5.3软件进行荟萃分析。
共纳入13项随机对照临床试验和12项前瞻性临床试验。荟萃分析显示，SRP术后2个月和3个月时血清CRP水平降低（P<0.05），6个月时血清CRP水平无显著差异（P=0.49）。
对于全身健康的中重度慢性牙周炎患者，SRP术后2个月和3个月时可降低血清CRP水平。
