血栓形成倾向筛查和血栓预防可能使特定族裔亚组的儿科急性淋巴细胞白血病患者受益。
Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia.
机构信息
Department of Paediatric Haematology and Oncology, Schneider Children's Medical Centre of Israel, Petach Tivka, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Paediatric Haematology-Oncology, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
出版信息
Br J Haematol. 2019 Mar;184(6):994-998. doi: 10.1111/bjh.15752. Epub 2019 Jan 10.
This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.
本研究调查了 2004 年至 2016 年间接受治疗的 476 名以色列急性淋巴细胞白血病（ALL）儿童中遗传性血栓形成倾向、静脉血栓栓塞（VTE）风险和低分子肝素预防的情况。血栓形成倾向的发生率为 15.5%。阿拉伯裔儿童 F5 R506Q（因子 V 莱顿）的发生率高于犹太裔儿童（19.4%比 2.9%，P<0.01）。有血栓形成倾向的患者 VTE（静脉血栓栓塞）发生率更高（26.5%比 5.6%，P<0.001）。未预防性治疗的血栓形成倾向患儿均无严重 VTE。对遗传性血栓形成倾向进行常规评估，并在发现阳性结果时进行血栓预防，可能会使 ALL 高危患者受益。
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