Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University, Daejeon, Republic of Korea.
Department of Biomedical Informatics, Konyang University, Daejeon, Republic of Korea.
Laryngoscope. 2019 Oct;129(10):2371-2377. doi: 10.1002/lary.27802. Epub 2019 Jan 10.
To evaluate the risk of cardio-cerebrovascular disease (CCVD), such as ischemic stroke and acute myocardial infarction (AMI), in patients diagnosed with Bell palsy STUDY DESIGN: Population-based follow-up study.
We used the National Sample Cohort 2002 to 2013 data from the Korea National Health Insurance Service. The Bell palsy group comprised all patients diagnosed with Bell palsy (n = 730). The comparison group comprised patients selected randomly using propensity score matching (n = 1,460). The Kaplan-Meier survival analysis, log-rank test, and Cox proportional-hazards regression models were used to calculate the disease-free survival rate and hazard ratio (HR) of CCVD for each group.
Of the total study population, ischemic stroke developed in 15.7% of patients with Bell palsy and 9% of patients in the comparison group during the 12-year follow-up period. After adjusting for other factors, the HR of ischemic stroke during the 12-year follow-up period was 1.84 times greater in the Bell palsy group than in the comparison group (95% confidence interval [CI], 1.43-2.36). However, the adjusted HR of developing ischemic stroke for patients with Bell palsy treated concurrently with antiviral agents and steroids was 1.12 (95% CI, 0.62.-2.04). There was no significant relationship between Bell palsy and risk of AMI development (HR, 1.13; 95% CI, 0.71-1.82).
Bell palsy is linked with an increased incidence of ischemic stroke. Our data suggest that Bell palsy may be used as an indicator of increased stroke risk, and concurrent treatment with antiviral agents and steroids may be effective in preventing ischemic stroke.
NA Laryngoscope, 129:2371-2377, 2019.
评估诊断为贝尔麻痹的患者发生心脑血管疾病（CCVD），如缺血性中风和急性心肌梗死（AMI）的风险。
基于人群的随访研究。
我们使用了韩国国家健康保险服务 2002 年至 2013 年的全国抽样队列 2002 年至 2013 年的数据。贝尔麻痹组包括所有诊断为贝尔麻痹的患者（n=730）。对照组由使用倾向评分匹配随机选择的患者组成（n=1460）。使用 Kaplan-Meier 生存分析、对数秩检验和 Cox 比例风险回归模型计算每组 CCVD 的无病生存率和风险比（HR）。
在总研究人群中，15.7%的贝尔麻痹患者和 9%的对照组患者在 12 年的随访期间发生缺血性中风。调整其他因素后，贝尔麻痹组在 12 年随访期间发生缺血性中风的 HR 是对照组的 1.84 倍（95%置信区间[CI]，1.43-2.36）。然而，同时接受抗病毒药物和类固醇治疗的贝尔麻痹患者发生缺血性中风的调整 HR 为 1.12（95%CI，0.62-2.04）。贝尔麻痹与发生 AMI 的风险无显著关系（HR，1.13；95%CI，0.71-1.82）。
贝尔麻痹与缺血性中风发生率增加有关。我们的数据表明，贝尔麻痹可能被用作增加中风风险的指标，同时使用抗病毒药物和类固醇治疗可能有效预防缺血性中风。
无 喉镜，129：2371-2377，2019。
