Faculty of Health, University of Canberra, Canberra, ACT, Australia.
Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, Australia.
Phytother Res. 2019 Mar;33(3):571-583. doi: 10.1002/ptr.6277. Epub 2019 Jan 10.
l-Theanine (l-THE) is a nonproteinogenic amino acid derived from green tea (Camellia sinensis), which exhibits strong antioxidant-like properties and contributes to the favourable umami taste sensation. Several studies have reported that the consumption of this amino acid has many therapeutic effects, including improvements in brain and gastrointestinal function, cancer drug therapeutic efficacies, antihypertensive effects, and improved immune function. Considering the recent Western commercialisation and popularity of green tea consumption as a nootropic agent in humans, the aims of this review were to consolidate the existing knowledge from ex vivo and in vitro animal models and attempt to highlight the applicability of l-THE towards the human clinical trials. Considering the anti-inflammatory and antioxidants effects of l-THE presented in the current review, further research must translate the existing knowledge gained from animal and cell models to exploring the potential metabolic health benefits and moderating effects on the pathogenesis of conditions such as obesity, arthritis, depression, and type 2 diabetes in human trials. This will bridge the gap in literature and provide more insights into the mechanisms driving pathologies characterised by the inflammatory response and oxidative stress.
l-茶氨酸（l-THE）是一种非蛋白氨基酸，来源于绿茶（Camellia sinensis），具有很强的抗氧化特性，并有助于产生令人愉悦的鲜味。多项研究报告称，这种氨基酸的摄入有许多治疗效果，包括改善大脑和胃肠道功能、癌症药物治疗效果、降压作用以及提高免疫功能。鉴于绿茶作为益智剂在西方的商业化和普及，本综述的目的是整合来自离体和在体动物模型的现有知识，并尝试强调 l-THE 对人类临床试验的适用性。考虑到 l-THE 在当前综述中表现出的抗炎和抗氧化作用，进一步的研究必须将从动物和细胞模型中获得的现有知识转化为探索其在代谢健康益处方面的潜在作用，以及在肥胖症、关节炎、抑郁症和 2 型糖尿病等疾病的发病机制中的调节作用。这将填补文献空白，并为炎症反应和氧化应激特征性病理的机制提供更多的见解。
