Rehman Mujeeb Ur, Bibi Saima, Khan Zahid, Khan Ahmed Saeed, Hussain Gilani Syed Yasir, Baig Mehreen
Department of Paediatric,Ayub Teaching Hospital Abbottabad, Pakistan.
Department of Paediatric,Ayub Teaching Hospital Abbottabad, Pakistann.
J Ayub Med Coll Abbottabad. 2018 Oct-Dec;30(4):529-533.
Childhood Tuberculosis remains one of the major public health concerns in developing countries like Pakistan and is responsible for high rates of morbidity and mortality in children. Although tuberculin skin test is very commonly used by physicians all over the world, its interpretation always remains difficult and challenging. The objective of this study was to determine the frequency of positive tuberculin skin test in vaccinated and unvaccinated children suffering from tuberculosis.
This Cross-sectional study was conducted in the department of Paediatric Ayub Teaching Hospital, Abbottabad from 1st February 2015 to 30th April 2016. A total of 150 patients were observed in this study. Children of either gender who were aged 1-15 years admitted in ward with tuberculosis were included in the study by using nonprobability convenient sampling technique. We injected 0.1 ml (10 units) of tuberculin purified protein derivative (PPD) into the anterior surface of the forearm and induration was read at 72 hours after administration. Data was entered and analysed using SPSS version 10.
Out of 150 children, 84 (56%) were males and 66 (44%) were females. The mean age was 7.8±3.84 years. Of these 75 (50%) were vaccinated and 75 (50%) were unvaccinated. In vaccinated Group 5.3% children had positive tuberculin skin test while in unvaccinated Group 2.7% children had positive tuberculin skin test and this difference was found statistically insignificant (pvalue= 0.40). Pulmonary TB was the diagnosis in 67 (44.7%), TBM in 65 (43.3%), abdominal TB in 7 (4.7%), disseminated TB in 4 (2.7%) and military TB in 7 (4.7%) patients.
The positivity of tuberculin skin test in vaccinated and unvaccinated children suffering from tuberculosis was found to be insignificant in our study. We conclude that Tuberculin Skin Test should not be used as a sole diagnostic tool for diagnosing the disease in children of our region..
儿童结核病仍是巴基斯坦等发展中国家主要的公共卫生问题之一，是导致儿童高发病率和死亡率的原因。尽管结核菌素皮肤试验在世界各地的医生中广泛使用，但其结果解读一直困难且具有挑战性。本研究的目的是确定接种疫苗和未接种疫苗的结核病患儿结核菌素皮肤试验阳性的频率。
本横断面研究于2015年2月1日至2016年4月30日在阿伯塔巴德阿尤布教学医院儿科进行。本研究共观察了150例患者。采用非概率方便抽样技术，将1-15岁因结核病入住病房的男女儿童纳入研究。我们将0.1毫升（10单位）结核菌素纯蛋白衍生物（PPD）注射到前臂前表面，并在给药后72小时读取硬结情况。使用SPSS 10版输入和分析数据。
150名儿童中，84名（56%）为男性，66名（44%）为女性。平均年龄为7.8±3.84岁。其中75名（50%）接种了疫苗，75名（50%）未接种疫苗。接种疫苗组5.3%的儿童结核菌素皮肤试验呈阳性，而未接种疫苗组2.7%的儿童结核菌素皮肤试验呈阳性，差异无统计学意义（p值=0.40）。67例（44.7%）诊断为肺结核，65例（43.3%）诊断为结核性脑膜炎，7例（4.7%）诊断为腹部结核，4例（2.7%）诊断为播散性结核，7例（4.7%）诊断为粟粒性结核。
在我们的研究中，接种疫苗和未接种疫苗的结核病患儿结核菌素皮肤试验阳性率无显著差异。我们得出结论，结核菌素皮肤试验不应作为我们地区儿童疾病诊断的唯一工具。
