Division of Chemical Biology and Drug Discovery, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Food Funct. 2019 Jan 22;10(1):33-37. doi: 10.1039/c8fo02376j.
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.
乳果糖是一种不可消化的低聚糖和功能性食品，可促进双歧杆菌生长。在这里，我们表明，乳果糖除了具有益生元作用外，还可能具有直接的免疫调节作用。在与细菌 DNA 模拟物 CpG-ODN 的协同作用下，乳果糖增强了上皮细胞和免疫细胞共培养模型中 IFN-γ、IL-10 和半乳糖凝集素-9 的基底外侧浓度。
