乳果糖与 CpG-ODN 协同作用调节上皮细胞和免疫细胞的串扰。
Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk.
机构信息
Division of Chemical Biology and Drug Discovery, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands.
出版信息
Food Funct. 2019 Jan 22;10(1):33-37. doi: 10.1039/c8fo02376j.
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.
乳果糖是一种不可消化的低聚糖和功能性食品，可促进双歧杆菌生长。在这里，我们表明，乳果糖除了具有益生元作用外，还可能具有直接的免疫调节作用。在与细菌 DNA 模拟物 CpG-ODN 的协同作用下，乳果糖增强了上皮细胞和免疫细胞共培养模型中 IFN-γ、IL-10 和半乳糖凝集素-9 的基底外侧浓度。
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