银催化吡啶-N-氧化物与炔烃的加成反应：一种制备 N-烯氧吡啶鎓盐的实用方法。
Silver(i)-catalyzed addition of pyridine-N-oxides to alkynes: a practical approach for N-alkenoxypyridinium salts.
机构信息
Department of Chemistry, Xuzhou Medical University, Xuzhou 221004, China.
出版信息
Org Biomol Chem. 2019 Jan 23;17(4):966-972. doi: 10.1039/c8ob02907e.
PMID:30632594
Abstract
A smooth catalytic approach to N-alkenoxypyridinium salts by using pyridine-N-oxides as the nucleophilic partner with alkynes under acidic conditions has been developed. This method uses different Ag(i) salts, with 5% AgOAc being the most efficient, to provide an efficient, practical and alternative way to obtain valuable N-alkenoxypyridinium salts with good to excellent yields (up to 93%).
摘要
在酸性条件下，利用吡啶-N-氧化物作为亲核试剂与炔烃反应，发展了一种制备 N-烯氧吡啶盐的温和催化方法。该方法使用不同的 Ag(i)盐，其中以 5% AgOAc 的效果最佳，为获得有价值的 N-烯氧吡啶盐提供了一种高效、实用且可替代的方法，产率良好至优秀（高达 93%）。
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