a Division of Periodontology, Department of Dental Medicine , Karolinska Institutet , Huddinge , Sweden.
b 1st Department of Therapeutic Dentistry , Belarusian State Medical University , Belarus.
Acta Odontol Scand. 2019 May;77(4):290-295. doi: 10.1080/00016357.2018.1541099. Epub 2019 Jan 11.
To evaluate the efficacy of adjunctive polyhexamethylene guanidine (PHMG) phosphate irrigation in periodontal treatment.
The subjects comprised 59 patients with severe chronic periodontitis. Plaque index, bleeding on probing (BOP) and pocket probing depths (PPD) were recorded. The subjects were randomly allocated to one of three groups for scaling and root planning, with different adjunctive irrigants: 1% PHMG phosphate (19 subjects), 0.2% chlorhexidine (21 subjects) and distilled water (19 subjects). Patients were recalled after two weeks, one month and then after 4, 6 and 12 months.
In all groups, treatment resulted in considerable improvement of the observed clinical parameters. There were no intergroup differences in plaque index and BOP at any time point, but significant differences in PPD at one, four and six months. By the end of the study no intergroup differences in PPDs persisted. While post study surgical treatment needs decreased in all three groups, no intergroup differences were observed in the number of deep periodontal pockets.
Irrigation with PHMG phosphate significantly reduces PPDs in the short-term, but has no significant long-term effect on the mean pocket depth.
评价聚六亚甲基胍磷酸盐（PHMG）辅助冲洗在牙周治疗中的疗效。
研究对象为 59 例重度慢性牙周炎患者。记录菌斑指数、探诊出血（BOP）和牙周袋探诊深度（PPD）。将患者随机分为三组进行洁治和根面平整，分别使用不同的辅助冲洗液：1% PHMG 磷酸盐（19 例）、0.2%洗必泰（21 例）和蒸馏水（19 例）。治疗后 2 周、1 个月及 4、6、12 个月进行随访。
所有组的观察临床参数均有显著改善。在任何时间点，菌斑指数和 BOP 均无组间差异，但 PPD 在 1、4 和 6 个月时有显著差异。研究结束时，PPD 无组间差异。尽管所有三组的术后手术治疗需求均减少，但深牙周袋数量无组间差异。
PHMG 磷酸盐冲洗在短期内显著降低 PPD，但对平均牙周袋深度无明显长期影响。
