Cui Yu, Wang Yu, Cao Rong, Liu Kai, Huang Qing-Hua, Liu Bin
Department of Anesthesiology, Chengdu Women's & Children's Central Hospital.
Department of Anesthesiology, Sichuan University West China Hospital.
Medicine (Baltimore). 2019 Jan;98(2):e14098. doi: 10.1097/MD.0000000000014098.
Fast-track anesthesia (FTA) is difficult to achieve in neonates due to immature organ function and high rates of perioperative events. As a high-risk population, neonates require prolonged postoperative mechanical ventilation, which may lead to contradictions in cases where neonatal intensive care unit resources and ventilator facilities are limited. The choice of anesthesia strategy and anesthetic can help achieve rapid postoperative rehabilitation and save hospitalization costs. The authors describe their experience with maintaining spontaneous breathing in neonates undergoing anoplasty without opioids or muscle relaxants.This retrospective chart review included neonates who underwent anoplasty in the authors' institution. Twelve neonates who underwent the procedure with atomized 5% lidocaine topical anesthesia around the glottis, combined with sevoflurane sedation and caudal anesthesia facilitating tracheal intubation without opioid and muscle relaxant comprised the FTA group. Ten neonates who underwent the intervention with routine anesthesia techniques in the same period comprised the control group (group C).The surgical success rate in the FTA group was 91.7%. There were no severe complications related to lidocaine administered around the glottis. Extubation time was significantly shorter in the FTA group than in group C (4 [2.5, 5.2] vs 81.5 [60.6, 96.8], respectively; P < .01). The duration of stay in the surgical intensive care unit (SICU) was longer in group C than in the FTA group (2 [2.0, 2.6] vs 1 [0.9, 2.0], respectively; P = .006,). A statistically significant lower rate of extubation-cough was noted after endotracheal tube removal in the FTA group compared with group C (18% vs 90%, respectively; P < .001). There was no difference in the duration of anesthesia or hospitalization costs between the 2 groups. No neonates required re-intubation after extubation.On-table extubation via 5% atomized lidocaine topical anesthesia around the glottis for tracheal intubation combined with sevoflurane sedation and caudal anesthesia without opioid and muscle relaxant was feasible in neonates undergoing anoplasty. This reduced time to extubation, length of SICU stay and saved resources. A similar trend in cost savings was also found; nevertheless, more studies are needed to confirm these results.
由于新生儿器官功能不成熟以及围手术期事件发生率高,快速通道麻醉(FTA)在新生儿中难以实现。作为高危人群,新生儿术后需要长时间机械通气,这在新生儿重症监护病房资源和呼吸机设施有限的情况下可能会导致矛盾。麻醉策略和麻醉剂的选择有助于实现术后快速康复并节省住院费用。作者描述了他们在无阿片类药物或肌肉松弛剂的情况下,在接受肛门成形术的新生儿中维持自主呼吸的经验。
这项回顾性图表审查纳入了在作者所在机构接受肛门成形术的新生儿。12名新生儿在声门周围采用5%利多卡因雾化局部麻醉,联合七氟醚镇静和骶管麻醉以促进气管插管,且无阿片类药物和肌肉松弛剂,组成FTA组。同期10名采用常规麻醉技术进行干预的新生儿组成对照组(C组)。
FTA组的手术成功率为91.7%。声门周围给予利多卡因未出现严重并发症。FTA组的拔管时间明显短于C组(分别为4[2.5,5.2]分钟和81.5[60.6,96.8]分钟;P<0.01)。C组在外科重症监护病房(SICU)的住院时间长于FTA组(分别为2[2.0,2.6]天和1[0.9,2.0]天;P = 0.006)。与C组相比,FTA组气管插管拔除后拔管咳嗽发生率显著降低(分别为18%和90%;P<0.001)。两组之间的麻醉持续时间或住院费用无差异。没有新生儿在拔管后需要重新插管。
对于接受肛门成形术的新生儿,通过声门周围5%利多卡因雾化局部麻醉用于气管插管,联合七氟醚镇静和骶管麻醉,且无阿片类药物和肌肉松弛剂,术中拔管是可行的。这缩短了拔管时间、SICU住院时间并节省了资源。在节省费用方面也发现了类似趋势;然而,需要更多研究来证实这些结果。