Carreras E, Lozano M, Deulofeu R, Roman S, Grañena A, Rozman C
Postgraduate School of Hematology, Hospital Clinic, University of Barcelona, Spain.
Bone Marrow Transplant. 1988 Nov;3(6):637-9.
We studied in vivo and in vitro the possible influence of the indwelling line on the measurement of cyclosporin A (CSA) levels. CSA levels measured in samples taken from the catheter lumen used for CSA administration were significantly higher than those taken either from a second lumen or from a peripheral vein. Reversible fixation of the drug to the catheter walls might explain this alteration. The degree of fixation varies for different types of plastic material.
我们在体内和体外研究了留置导管对环孢素A（CSA）水平测量的可能影响。从用于输注CSA的导管管腔采集的样本中测得的CSA水平显著高于从第二个管腔或外周静脉采集的样本中的水平。药物与导管壁的可逆性结合可能解释了这种差异。不同类型的塑料材料的结合程度各不相同。
