HIDRAdisk：评估化脓性汗腺炎负担的创新视觉工具的验证。
HIDRAdisk: validation of an innovative visual tool to assess the burden of hidradenitis suppurativa.
机构信息
Istituto di Dermatologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore, Rome, Italy.
Unità di Dermatologia, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.
出版信息
J Eur Acad Dermatol Venereol. 2019 Apr;33(4):766-773. doi: 10.1111/jdv.15425. Epub 2019 Mar 5.
BACKGROUND
Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterized by painful inflamed nodules, recurrent abscesses and fistulas located in apocrine gland-bearing body sites. The negative impact of HS on patient's quality of life (QoL) has been reported to be greater than other dermatologic conditions as psoriasis and atopic eczema, and its improvement is an important goal in disease management. Nowadays, there are no specific validated QoL instruments available for HS and generic dermatologic questionnaires are used.
OBJECTIVE
The objective of this study was to demonstrate the validity, reliability and responsiveness of HIDRAdisk, a new innovative tool designed for rapid assessment of HS burden and, at the same time, an intuitive graphic visualization of the measurement outcome.
METHODS
A multicentre, longitudinal, observational study was conducted to validate the HIDRAdisk compared with other validated questionnaires [Skindex-16, Dermatology Life Quality Index (DLQI), Work Productivity and Activity Impairment-General Health (WPAI:GH)] and to evaluate its correlation with disease severity in Italian patients with any degree of HS severity, as measured by Hurley stage and HS Physician Global Assessment (HS-PGA).
RESULTS
A total of 140 patients (59% women; mean age 34.9 ± 11.0 years) were enrolled in 27 dermatologic centres. HIDRAdisk showed a strong correlation with Skindex-16 and DLQI, and a good one with WPAI:GH (correlation coefficient: 0.7568, 0.6651 and 0.5947, respectively) and a statistically significant correlation with both Hurley stage and HS-PGA. Very good internal consistency (Cronbach coefficient >0.80; intraclass correlation coefficient >0.6), with correlation between the 10 items, good test-retest reliability (Spearman correlation coefficient, 0.8331; P < 0.0001) and responsiveness to changes were demonstrated.
CONCLUSION
Our study shows that HIDRAdisk, a short and innovative visual HS QoL instrument, has been psychometrically validated in Italian language and it may help improve the management of HS once implemented in routine clinical practice.
背景
化脓性汗腺炎（HS）是一种慢性、复发性、炎症性皮肤病，其特征为疼痛性炎症性结节、反复发作的脓肿和位于顶泌腺部位的瘘管。与银屑病和特应性皮炎等其他皮肤病相比，HS 对患者生活质量（QoL）的负面影响更大，改善 HS 是疾病管理的重要目标。目前，尚无专门针对 HS 的经过验证的 QoL 工具，而是使用通用的皮肤科问卷。
目的
本研究旨在证明 HIDRAdisk 的有效性、可靠性和反应性，HIDRAdisk 是一种新的创新工具，用于快速评估 HS 负担，同时直观地显示测量结果。
方法
进行了一项多中心、纵向、观察性研究，以验证 HIDRAdisk 与其他经过验证的问卷（Skindex-16、皮肤病生活质量指数（DLQI）、工作效率和活动障碍-一般健康（WPAI：GH））的相关性，并评估其与意大利任何严重程度 HS 患者（根据 Hurley 分期和 HS 医生整体评估（HS-PGA））疾病严重程度的相关性。
结果
共纳入 140 例患者（59%为女性；平均年龄 34.9±11.0 岁），来自 27 个皮肤科中心。HIDRAdisk 与 Skindex-16 和 DLQI 具有很强的相关性，与 WPAI:GH 也具有良好的相关性（相关系数分别为 0.7568、0.6651 和 0.5947），与 Hurley 分期和 HS-PGA 也具有统计学显著相关性。HIDRAdisk 具有非常好的内部一致性（Cronbach 系数>0.80；组内相关系数>0.6），10 个项目之间具有相关性，具有良好的重测信度（Spearman 相关系数，0.8331；P<0.0001）和对变化的反应能力。
结论
我们的研究表明，HIDRAdisk 是一种简短而创新的视觉 HS QoL 工具，已在意大利语中进行了心理测量学验证，一旦在常规临床实践中实施，它可能有助于改善 HS 的管理。
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