术前中性粒细胞与淋巴细胞比值而非血小板与淋巴细胞比值可预测口腔、咽和唇癌患者的生存和早期复发。
Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer.
机构信息
Institute of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Department of Oncology, Yantai affiliated Hospital of Binzhou Medicial University, Yantai, Shandong, China.
出版信息
Head Neck. 2019 May;41(5):1468-1474. doi: 10.1002/hed.25580. Epub 2019 Jan 11.
BACKGROUND
To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse.
METHODS
Clinic-pathologic and hematological records were retrospectively retrieved. Patients completed follow-up period were included for survival and relapse analysis.
RESULTS
The preoperative NLR value was a prognostic factor for both overall survival and relapse-free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse.
CONCLUSIONS
The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.
背景
评估术前中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在口腔、咽和唇癌患者的生存和复发中的预后价值。
方法
回顾性检索临床病理和血液学记录。完成随访的患者被纳入生存和复发分析。
结果
术前 NLR 值是总生存和无复发生存的预后因素。高 NLR 组的总复发率、局部复发率和 12 个月内复发率均较高。然而，术前 PLR 与生存或复发无关。
结论
术前 NLR（而非 PLR）是生存的独立预后指标。它对复发也具有预测价值，特别是 12 个月内的早期复发。术前 NLR 值可能被推荐作为一种有用的工具，用于预测结局和为不同的管理策略分层患者。
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