头颈部副神经节瘤的放射治疗：一项罕见癌症网络研究。
Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study.
机构信息
Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Head Neck. 2019 Jun;41(6):1770-1776. doi: 10.1002/hed.25611. Epub 2019 Jan 11.
BACKGROUND
Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network.
METHODS
Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed.
RESULTS
The median follow-up was 48 months (1-456). Sixty-two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow-up longer than 20 years experienced disease progression.
CONCLUSION
RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long-term follow-up is required.
背景
头颈部副神经节瘤（HNPGL）是一种罕见的良性肿瘤。手术和放射治疗（RT）是主要的治疗选择。我们分析了罕见癌症网络 13 个机构的 RT 治疗后的结果和毒性。
方法
通过问卷调查收集了患者特征、治疗和结果的数据。共分析了 81 例 82 个 HNPGL。
结果
中位随访时间为 48 个月（1-456）。62 个病灶接受常规 RT 治疗，20 个病灶接受立体定向 RT 治疗。77 个病灶中有 69 个获得了局部控制。17 例患者出现迟发性毒性。接受立体定向 RT 治疗的患者既没有疾病进展，也没有迟发性毒性。4 例随访时间超过 20 年的患者出现疾病进展。
结论
RT 治疗 HNPGL 具有良好的局部控制效果，且毒性可接受。立体定向 RT 可能会有更好的效果。需要长期随访。
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