Department of Dermatology, Venereology and Andrology, Aswan University, Aswan, Egypt.
Department of Dermatology, Venereology and Andrology, South Valley, University, Qena, Egypt.
Aging Male. 2020 Dec;23(5):579-584. doi: 10.1080/13685538.2018.1548590. Epub 2019 Jan 11.
Varicocele is one of the most common causes of male infertility. Leptin that has a role in sperm motility may have a role of varicocele. We aimed to study the effect of varicocelectomy on the serum and seminal leptin in patients with asthenozoospermia and the correlation between leptin levels, sperm parameters and varicocele grade.
Thirty-six male patients with varicocele having isolated asthenozoospermia were included in this study. Thirty normal fertile controls were included. Semen analysis, serum and seminal leptin measurements were performed for all participants at baseline and for patients three months after varicocelectomy. Microsurgical varicocelectomy has been performed for patients.
Seminal and serum leptin levels were significantly higher in patients than controls. Seminal leptin was positively correlated with varicocele grade ( = 0.357, < .05) while no correlation was found between serum leptin varicocele grade ( = 0.056, = .37). Both seminal and serum leptin were inversely correlated with sperm motility ( = -0.92 and = -0.87, < .001; respectively). Seminal and serum leptin were significantly improved after varicocelectomy.
Varicocele is associated with higher levels of seminal and serum leptin especially in higher grads and this was correlated with negative effects on sperm motility. Leptin levels were significantly decreased after repair.
精索静脉曲张是男性不育的最常见原因之一。瘦素在精子活力中起作用，可能在精索静脉曲张中起作用。我们旨在研究精索静脉结扎术对弱精子症患者血清和精液瘦素的影响，以及瘦素水平、精子参数和精索静脉曲张分级之间的相关性。
本研究纳入了 36 名患有孤立性弱精子症的精索静脉曲张男性患者。纳入了 30 名正常生育力的对照组。所有参与者均在基线时和精索静脉曲张结扎术后 3 个月进行精液分析、血清和精液瘦素测量。对患者进行了显微精索静脉结扎术。
患者的精液和血清瘦素水平明显高于对照组。精液瘦素与精索静脉曲张分级呈正相关（ = 0.357， < .05），而血清瘦素与精索静脉曲张分级之间无相关性（ = 0.056， = .37）。精液和血清瘦素均与精子活力呈负相关（ = -0.92 和 = -0.87， < .001；分别）。精索静脉曲张结扎术后，精液和血清瘦素均显著改善。
精索静脉曲张与较高水平的精液和血清瘦素相关，尤其是在较高分级中，这与精子活力的负面影响相关。修复后瘦素水平显著降低。
