Guo Jianhua, Zhao Yang, Huang Weiying, Hu Wei, Gu Jianjun, Chen Chuhong, Zhou Juan, Peng Yubing, Gong Min, Wang Zhong
Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 200011, China ; Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Centre Shanghai 201399, China.
Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 200011, China.
Int J Clin Exp Med. 2014 Oct 15;7(10):3550-5. eCollection 2014.
Asthenozoospermia is one kind cause of male infertility. Nevertheless, no specific etiology can be identified by routine tests in some cases. Recently, it has been shown that leptin plays a critical role in male fertility. However, the link between leptin and sperm motility is yet to be determined. The aim of this study was to explore association between seminal and serum leptin levels and sperm motility in idiopathic asthenozoospermia.
Our study included 79 asthenozoospermic men and 77 normozoospermic men. Semen was assessed by volume, sperm concentration, motility and morphology. Serum gonadotropic and sex hormones were determined by a chemiluminescent assay. The leptin levels in serum and seminal plasma were detected with ELISA.
The mean seminal leptin level in asthenozoospermic group was significantly higher than that in control group, but there was no significant difference in the serum leptin levels between these two groups. The serum leptin had no significant correlation with sperm motility. The seminal leptin had significantly negative correlation with sperm progressive motility and serum total testosterone.
The findings indicate a pathophysiological relevance of seminal leptin in sperm motility.
弱精子症是男性不育的一种原因。然而，在某些情况下，常规检查无法确定具体病因。最近的研究表明，瘦素在男性生育中起着关键作用。然而，瘦素与精子活力之间的联系尚未确定。本研究的目的是探讨特发性弱精子症患者精液和血清瘦素水平与精子活力之间的关联。
我们的研究纳入了79例弱精子症男性和77例正常精子症男性。通过精液量、精子浓度、活力和形态对精液进行评估。采用化学发光法测定血清促性腺激素和性激素。用酶联免疫吸附测定法检测血清和精浆中的瘦素水平。
弱精子症组的平均精浆瘦素水平显著高于对照组，但两组血清瘦素水平无显著差异。血清瘦素与精子活力无显著相关性。精浆瘦素与精子前向运动能力和血清总睾酮显著负相关。
研究结果表明精浆瘦素在精子活力方面具有病理生理学意义。
