Department of Pharmacy, The People's Hospital of Danyang, Danyang, China.
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
J Med Virol. 2019 Jun;91(6):1097-1103. doi: 10.1002/jmv.25398. Epub 2019 Jan 21.
To investigate the association between two RIG-I-like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population.
The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non-HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients).
IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07-1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15-1.78; P = 0.001) were associated with chronic hepatitis C (CHC). And the risk of CHC increased when people were carrying more unfavorable rs3747517-GA/AA and rs9695310-GC/CC genotypes from zero to two with the chronic rates of 56.72%, 59.38%, and 69.01%, respectively (P < 0.001).
Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population.
研究两种 RIG-I 样受体基因多态性与中国汉族人群丙型肝炎病毒（HCV）感染的关系。
本研究采用 TaqMan 等位基因鉴别分析，对两个选定的 SNP（IFIH1 rs3747517 和 DDX58 rs9695310）进行基因分型，以评估它们与 HCV 感染易感性和临床结局的关系，共纳入 3065 名参与者（1545 名非 HCV 感染个体、568 例自发性 HCV 清除病例和 952 例持续性感染患者）。
IFIH1 rs3747517（显性模型：调整后的优势比[OR] = 1.34，95%置信区间[CI] = 1.07-1.68；P = 0.009）和 DDX58 rs9695310（显性模型：调整后的 OR = 1.43，95% CI = 1.15-1.78；P = 0.001）与慢性丙型肝炎（CHC）相关。当个体携带更多不利的 rs3747517-GA/AA 和 rs9695310-GC/CC 基因型时，CHC 的风险增加，从零到两个基因型的慢性率分别为 56.72%、59.38%和 69.01%（P < 0.001）。
IFIH1 rs3747517 和 DDX58 rs9695310 的遗传变异是中国汉族人群慢性丙型肝炎的独立预测因子。
