用于治疗产后抑郁症的 GABA 调节剂。
GABAR Modulator for Postpartum Depression.
机构信息
Departments of Neurology and Physiology, The David Geffen School of Medicine at UCLA, 635 Charles Young Dr. E., Los Angeles, CA 90095, USA.
出版信息
Cell. 2019 Jan 10;176(1-2):1. doi: 10.1016/j.cell.2018.12.016.
During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid during the postpartum period to alleviate the mood disorder. To view this Bench to Bedside, open or download the PDF.
在产后期间，大脑的抑制性 GABAA 受体在怀孕期间数量减少后可能无法及时恢复。这可能是产后抑郁症在约 12%的育龄妇女中普遍存在的原因。这种情况的一种新疗法是在产后期间给予合成神经甾体以缓解情绪障碍。要查看此从实验室到病床的转化，请打开或下载 PDF。
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