Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Cell. 2019 Jan 10;176(1-2):2-4. doi: 10.1016/j.cell.2018.12.027.
With the advent of more successful chemotherapies, the number of cancer survivors continues to increase. Unfortunately, many of these patients will exhibit long-term sequelae from their treatments, including serious cognitive deficits that impair daily function. In this issue of Cell, Gibson et al. (2019) demonstrate that chemotherapy-related cognitive impairment is orchestrated by microglia.
随着更成功的化疗方法的出现，癌症幸存者的数量继续增加。不幸的是，这些患者中的许多人将表现出他们的治疗带来的长期后遗症，包括严重的认知缺陷，损害日常功能。在本期《细胞》杂志上，Gibson 等人（2019）表明，化疗相关的认知障碍是由小胶质细胞协调的。
