Department of Chemistry, Jadavpur University, Kolkata 700032, India.
Department of Chemistry, Vivekananda College, Thakurpukur, Kolkata 700063, India.
Int J Biol Macromol. 2019 Apr 15;127:520-528. doi: 10.1016/j.ijbiomac.2019.01.031. Epub 2019 Jan 8.
The current work describes the efficacy of an artificially synthesized Gd(III) complex as a potential radioprotecting molecule. The work involves utilization of spectroscopic and electrophoretic techniques to investigate the radioprotecting behavior of the Gd(III) complex. Spectroscopic studies revealed that the complex interacted strongly with DNA while molecular docking studies suggested groove binding through H-bond formation and other non-covalent interactions. The Gd(III) complex was found to impart 94% and 91% protection to irradiatively damaged DNA at radiation doses of 20 and 25 Gy respectively. The protection is believed to occur via radical scavenging mechanism and the antioxidant behavior of the complex suggested a strong radical scavenging property.
本工作描述了一种人工合成的 Gd(III) 配合物作为潜在的辐射防护分子的功效。该工作涉及利用光谱和电泳技术研究 Gd(III) 配合物的辐射防护行为。光谱研究表明，该配合物与 DNA 强烈相互作用，而分子对接研究表明通过氢键形成和其他非共价相互作用进行沟结合。在辐射剂量为 20 和 25 Gy 时，Gd(III) 配合物分别对受照射损伤的 DNA 赋予 94%和 91%的保护。据信，这种保护是通过自由基清除机制发生的，并且配合物的抗氧化行为表明其具有很强的自由基清除特性。
