人羊膜在角膜缘干细胞缺乏症手术治疗中的应用。
The application of human amniotic membrane in the surgical management of limbal stem cell deficiency.
机构信息
Stein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, USA; Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Stein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, USA.
出版信息
Ocul Surf. 2019 Apr;17(2):221-229. doi: 10.1016/j.jtos.2019.01.003. Epub 2019 Jan 8.
Abstract
The application of human amniotic membrane (AM) has a wide spectrum of indications in the treatment of ocular surface disorders. Transplantation of AM has been incorporated routinely as a component of ocular surface reconstruction in a variety of ocular pathologies. The application of human AM can be combined with nearly all types of limbal transplantation in treating limbal stem cell deficiency (LSCD). AM provides support and possible protection to the transplanted limbal tissues and limbal stem cells owing to its mechanical and biological properties, and these properties are thought to enhance the success rate of LSC transplantation. This paper reviews the current literature on the applications of AM in the surgical management of LSCD and summarizes the outcome of different surgical approaches. The current literature contains mostly low-level evidences in supporting the role of AM. The efficacy of AM in LSC transplantation needs to be confirmed by randomized controlled clinical trials.
摘要
人羊膜（AM）的应用在治疗眼表疾病方面有广泛的适应症。AM 的移植已常规纳入各种眼病理中的眼表重建的组成部分。人 AM 的应用可以与几乎所有类型的角膜缘移植相结合，用于治疗角膜缘干细胞缺陷（LSCD）。由于其机械和生物学特性，AM 为移植的角膜缘组织和角膜缘干细胞提供支持和可能的保护，这些特性被认为可以提高 LSC 移植的成功率。本文综述了 AM 在 LSCD 手术治疗中的应用的当前文献，并总结了不同手术方法的结果。目前的文献中大多为低水平证据支持 AM 的作用。AM 在 LSC 移植中的疗效需要通过随机对照临床试验来证实。
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本文引用的文献
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The diagnosis of limbal stem cell deficiency.角膜缘干细胞缺乏的诊断。
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Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets.无生物材料培养口腔黏膜上皮细胞片用于角膜重建的前瞻性临床试验。
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Modified Allogenic Simple Limbal Epithelial Transplantation Followed by Keratoplasty as Treatment for Total Limbal Stem Cell Deficiency.同种异体单纯性角膜缘上皮移植联合角膜移植治疗完全性角膜缘干细胞缺乏症。
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