Department of Obstetrics and Gynecology, Yeditepe University, Turkey.
Independent Researcher.
Cell Mol Biol (Noisy-le-grand). 2021 Nov 25;67(3):212-223. doi: 10.14715/cmb/2021.67.3.34.
Wealth of information has revolutionized our understanding related to the genetics and functional genomics of this heterogeneous disease. Keeping in view the heterogeneity of ovarian cancer, long-term survival might be achieved by translation of recently emerging mechanistic insights at the cellular and molecular levels to personalize individual strategies for treatment and to identify biomarkers for early detection. Importantly, the motility and invasive properties of ovarian cancer cells are driven by a repertoire of signaling cascades, many components of which have been experimentally verified as therapeutic targets in preclinical models as well as in clinical trials. Scientific evidence garnered over decades of research has deconvoluted the highly intricate intertwined network of intracellular signaling pathways which played fundamental role in carcinogenesis and metastasis. In this review we have provided a compendium of myriad of signaling cascades which have been documented to play critical role in the progression and metastasis of ovarian cancer. We have partitioned this multi-component review into different sections to individually discuss and summarize the roles of TGF/SMAD, JAK/STAT, Wnt/β-Catenin, NOTCH, SHH/GLI, mTORC1/mTORC2, VEGFR and Hippo/YAP pathways in ovarian cancer metastasis.
大量的信息已经彻底改变了我们对这种异质性疾病的遗传学和功能基因组学的理解。鉴于卵巢癌的异质性，通过将最近在细胞和分子水平上出现的机制见解转化为个性化的治疗策略，并识别早期检测的生物标志物，可能实现长期生存。重要的是，卵巢癌细胞的运动和侵袭特性是由一系列信号级联驱动的，其中许多成分已在临床前模型和临床试验中作为治疗靶点得到实验验证。数十年来的研究积累的科学证据已经阐明了在致癌作用和转移中起基本作用的细胞内信号通路的高度复杂的交织网络。在这篇综述中，我们提供了大量已被证明在卵巢癌进展和转移中起关键作用的信号级联的概述。我们将这个多组分综述分成不同的部分，分别讨论和总结 TGF/SMAD、JAK/STAT、Wnt/β-Catenin、NOTCH、SHH/GLI、mTORC1/mTORC2、VEGFR 和 Hippo/YAP 通路在卵巢癌转移中的作用。
