Munoz Jessian L
OB/GYN and Women's Health Institute A81, Cleveland Clinic, Cleveland, OH, 44105, USA.
J Gynecol Obstet Hum Reprod. 2019 Apr;48(4):231-233. doi: 10.1016/j.jogoh.2019.01.001. Epub 2019 Jan 8.
Fetal thyroid disorders while uncommon in general, have significant morbidity and profound effects in the neonate. Pregnancy provides the opportunity not only for the diagnosis of these conditions but also for therapeutic interventions. In careful balance, these disorders range from hypothyroidism to hyperthyroidism, both may manifest with fetal thyroid goiters as well. The intrauterine therapeutic approach of these must also weight the balance in this range as well as the maternal well being which may also express thyroid dysfunction. In this review we explore the different fetal manifestations of thyroid disease, describe the pathophysiology and therapeutic approaches both in practice and in development.
胎儿甲状腺疾病总体上虽不常见，但在新生儿中具有显著的发病率和深远影响。妊娠不仅为诊断这些疾病提供了机会，也为治疗干预创造了条件。需要谨慎权衡的是，这些疾病涵盖了甲状腺功能减退到甲状腺功能亢进，两者都可能伴有胎儿甲状腺肿大。对这些疾病的宫内治疗方法也必须在这个范围内权衡利弊，同时还要考虑到可能也表现出甲状腺功能障碍的母体健康状况。在这篇综述中，我们探讨了甲状腺疾病的不同胎儿表现，描述了其病理生理学以及实际应用和正在研发中的治疗方法。
