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甲状腺功能正常的患者诊断出胎儿甲状腺肿:胎儿甲状腺疾病的一种罕见表现

Fetal Goiter Diagnosed in a Euthyroid Patient: An Unusual Presentation of the Fetal Thyroid Disease.

作者信息

Parra Meza Carolina, Africano León Martha L, Quintero Reyes Natalia, Suarez Mantilla Silvia N, Alvarez Orduz Claudia Patricia

机构信息

Gynecology and Obstetrics, Hospital Universitario de Santander, Bucaramanga, COL.

Maternal and Fetal Medicine, Universidad Industrial de Santander, Bucaramanga, COL.

出版信息

Cureus. 2023 Jul 6;15(7):e41483. doi: 10.7759/cureus.41483. eCollection 2023 Jul.

DOI:10.7759/cureus.41483
PMID:37551241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10404307/
Abstract

Fetal thyroid disease is rare, and the disease is mostly contextualized in the setting of a treated maternal thyroid disease. The presentation of thyroid disease in the fetus of a euthyroid mother is unusual. This paper presents the case of a 21-week pregnant woman with an incidental finding from a detailed anatomy ultrasound and evaluates available diagnostic and therapeutic management options. There is no consensus with sufficient evidence given the unusual presentation of this type of pathology. In most cases, the evidence is in the etiology of a mother with previous thyroid pathology that modifies the fetal outcome. Hence, it is important to describe cases to accumulate and, at some point, sufficient evidence of different treatments, with the intention of improving the quality of the recommendations. The management of fetal euthyroid goiter is a complex challenge. Most specialists manage the information on a case-by-case basis, with the same general goals as in patients with other thyroid pathologies.

摘要

胎儿甲状腺疾病较为罕见,且该疾病大多与已接受治疗的母体甲状腺疾病相关。甲状腺功能正常的母亲所怀胎儿出现甲状腺疾病的情况并不常见。本文介绍了一名21周孕妇的病例,该孕妇在详细的解剖超声检查中意外发现相关情况,并评估了现有的诊断和治疗管理方案。鉴于这类病理情况的不寻常表现,目前尚无足够证据支持的共识。在大多数情况下,证据存在于有既往甲状腺病理情况的母亲的病因中,这会改变胎儿的结局。因此,描述病例以积累不同治疗方法的充分证据很重要,目的是提高建议的质量。胎儿甲状腺功能正常的甲状腺肿的管理是一项复杂的挑战。大多数专家逐案处理信息,其总体目标与其他甲状腺疾病患者相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/f30fa501d64c/cureus-0015-00000041483-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/fa7ddba1856a/cureus-0015-00000041483-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/1f024b3d1e7f/cureus-0015-00000041483-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/92c18d882923/cureus-0015-00000041483-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/3cf954abaf5e/cureus-0015-00000041483-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/f30fa501d64c/cureus-0015-00000041483-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/fa7ddba1856a/cureus-0015-00000041483-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/1f024b3d1e7f/cureus-0015-00000041483-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/92c18d882923/cureus-0015-00000041483-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/3cf954abaf5e/cureus-0015-00000041483-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753c/10404307/f30fa501d64c/cureus-0015-00000041483-i05.jpg

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本文引用的文献

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Thyroid Function During the Fetal and Neonatal Periods.胎儿和新生儿期的甲状腺功能。
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Maternal and Fetal Thyroid Physiology.母婴甲状腺生理学
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Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis.因激素合成障碍导致的胎儿甲状腺肿性甲状腺功能减退症的产前诊断与管理
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Management of fetal goiters: 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays De Loire Perinatal Network.胎儿甲状腺肿的管理:卢瓦尔河地区围产期网络三个产前诊断与治疗中心的6年回顾性观察研究
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Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.羊膜腔内注射三碘甲状腺原氨酸和甲状腺素治疗胎儿甲状腺肿性甲状腺功能减退症(与羊水过多相关且由甲状腺球蛋白突变引起)后发生的宫内死亡
Endocrinol Diabetes Metab Case Rep. 2017 Jun 7;2017. doi: 10.1530/EDM-17-0040. eCollection 2017.
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Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachment.胎儿及新生儿甲状腺功能亢进症:诊断与治疗方法
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