延胡索属中具有胆碱酯酶抑制作用的异喹啉生物碱。
Cholinesterase inhibitory isoquinoline alkaloids from Corydalis mucronifera.
机构信息
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
Medical College of Tibet University, Lhasa, 850000, People's Republic of China.
出版信息
Phytochemistry. 2019 Mar;159:199-207. doi: 10.1016/j.phytochem.2018.11.019. Epub 2019 Jan 9.
Eight previously undescribed isoquinoline alkaloids, mucroniferanines H-M, together with 16 known isoquinoline alkaloids, were isolated from Corydalis mucronifera Maxim.. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic and HRMS data, and their absolute configurations were established by computational electronic circular dichroism (ECD) calculations and X-ray diffraction data. Mucroniferanine L is reported as the first natural amide bond linked isoquinoline alkaloid dimer. The isolated compounds were evaluated for AChE and BuChE inhibitory activities and mucroniferanine H showed significant activities with IC values of 2.31 μM and 36.71 μM, respectively.
从延胡索中分离得到了 8 种以前未描述过的异喹啉生物碱，即 mucroniferanines H-M，以及 16 种已知的异喹啉生物碱。通过对 1D 和 2D NMR 光谱和高分辨质谱（HRMS）数据的解析，确定了以前未描述化合物的结构，并通过计算电子圆二色谱（ECD）计算和 X 射线衍射数据确定了它们的绝对构型。mucroniferanine L 是报道的第一个天然酰胺键连接的异喹啉生物碱二聚体。对分离得到的化合物进行乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）抑制活性评价，结果显示 mucroniferanine H 具有显著的活性，IC50 值分别为 2.31 μM 和 36.71 μM。
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