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阿马瑞利氏科植物的生物活性及与老年痴呆症相关的进一步异喹啉生物碱的最新进展。

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer's Disease.

机构信息

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.

Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.

出版信息

Molecules. 2021 Aug 29;26(17):5240. doi: 10.3390/molecules26175240.

DOI:10.3390/molecules26175240
PMID:34500673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8434202/
Abstract

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.

摘要

阿尔茨海默病（AD）是一种进行性与年龄相关的神经退行性疾病，是老年人中最常见的痴呆症形式。由于 AD 的确切发病机制仍未完全阐明，因此治疗方法只是对症治疗，可用的药物无法改变 AD 的进展。考虑到全球预期寿命的增加，AD 发病率预计将大幅上升，因此迫切需要寻找新的 AD 药物。由于其复杂的含氮结构，生物碱被认为是治疗 AD 的有前途的候选药物。自 2001 年加兰他敏作为抗痴呆药物问世以来，石蒜科生物碱（AAs）和进一步的异喹啉生物碱（IAs）一直是研究最多的生物碱之一。在过去的几年中，已经分离出了几种具有新结构类型的化合物，并对其与 AD 相关的生物活性进行了评估。本综述旨在全面总结 2010 年至 2021 年 6 月期间 AAs 和 IAs 作为治疗 AD 的潜在药物的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/ff174b62176d/molecules-26-05240-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/f686c918ecb0/molecules-26-05240-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/f08923979a24/molecules-26-05240-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/ff174b62176d/molecules-26-05240-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/409967150bac/molecules-26-05240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/5cf426e31630/molecules-26-05240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/bee9e5900d9f/molecules-26-05240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/e565bc230e79/molecules-26-05240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/7ddd5b871a52/molecules-26-05240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/640271d71013/molecules-26-05240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/f686c918ecb0/molecules-26-05240-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/f08923979a24/molecules-26-05240-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/8434202/ff174b62176d/molecules-26-05240-g009.jpg

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