Department of Haematology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
Semin Thromb Hemost. 2019 Feb;45(1):100-107. doi: 10.1055/s-0038-1677042. Epub 2019 Jan 11.
Disseminated intravascular coagulation (DIC) is an intermediary mechanism of disease known to develop as a complication in other conditions like sepsis, trauma, cancer, or obstetrical disorders. Patients with DIC may present to different specialists depending on symptomology and as such a good understanding of the pathophysiological process is necessary to ensure best management. However, more recently, controversy has risen where experts doubt whether DIC really exists in many of the historically well-established diagnoses. This has led to confusion among both basic science researchers and clinical practitioners about when to consider DIC diagnosis. In this review, the various issues which have led to this uncertainty are addressed, including the problem with different terminologies, simpler explanation of current DIC diagnostic criteria, and reasons behind why the diagnosis may be overlooked or not considered at all, along with their possible solutions. It is hoped that the diagnostic aspects of DIC will come full circle, wherein the recent research can build up on what history had taught us and not refute its existence.
弥散性血管内凝血(DIC)是一种已知的疾病中介机制，它作为其他疾病如脓毒症、创伤、癌症或产科疾病的并发症而发展。DIC 患者可能根据症状表现就诊于不同的专科医生，因此，为了确保最佳管理，需要对病理生理过程有很好的理解。然而，最近，专家们对许多历史上确立的诊断中是否真的存在 DIC 产生了怀疑，这导致基础科学研究人员和临床医生在何时考虑 DIC 诊断时感到困惑。在这篇综述中，讨论了导致这种不确定性的各种问题，包括不同术语的问题、当前 DIC 诊断标准的更简单解释，以及为什么可能会忽略或根本不考虑诊断的原因，以及可能的解决方案。希望 DIC 的诊断方面能够全面展开，即最近的研究能够在历史所教给我们的基础上有所发展，而不是否定其存在。
