Schoenberger J A
Rush-Presbyterian-St Luke's Medical Center, Chicago.
Drugs. 1988;35 Suppl 5:74-9. doi: 10.2165/00003495-198800355-00013.
Quality of life is of growing concern in the management of chronic illnesses such as hypertension. This has become increasingly so as mild to moderate primary hypertension, almost always asymptomatic, is treated more aggressively with a variety of agents which lower blood pressure, but are associated with adverse side effects. The short term benefit of treatment of mild high blood pressure is minimal; only sustained long term treatment can hope to offer therapeutic benefit. Assessment of the quality of life is not standardised. Perception of the quality of life as seen by the physician, the patient, and the patient's close relatives may differ widely, and no absolute, objective measurements are available. Recent studies have shown that questionnaires completed by the patient can assess the overall response of the hypertensive patient to the treatment administered. Drugs differ significantly in their effect on the quality of life as perceived by the patient, and so assessment of the quality of life by these new methods offers the promise of selecting drugs with the most favourable effect. This should ensure better compliance with the drug regimen and a greater expectation that long term treatment can be maintained until significant benefit accrues.
在高血压等慢性病的管理中，生活质量日益受到关注。随着轻度至中度原发性高血压（几乎总是无症状）越来越多地使用各种降压药物进行积极治疗，但这些药物会带来不良副作用，情况更是如此。轻度高血压治疗的短期益处微乎其微；只有持续的长期治疗才有希望带来治疗益处。生活质量的评估尚未标准化。医生、患者及其近亲对生活质量的认知可能存在很大差异，而且没有绝对客观的测量方法。最近的研究表明，患者填写的问卷可以评估高血压患者对所接受治疗的总体反应。不同药物对患者所感知的生活质量的影响差异很大，因此通过这些新方法评估生活质量有望选择出效果最有利的药物。这应能确保更好地遵守药物治疗方案，并更有希望维持长期治疗，直到获得显著益处。
