J Phys Act Health. 2019 Feb 1;16(2):134-140. doi: 10.1123/jpah.2017-0644. Epub 2019 Jan 11.
To investigate the association between cardiorespiratory fitness and risk of cardiovascular disease, cancer, and all-cause mortality in men with musculoskeletal conditions.
Participants were 12,728 men (mean age 47.0 [9.3] y) with a history of musculoskeletal conditions (including joint pain, low back pain, stiff joints, arthritis, osteoporosis, or gout) and were followed for all-cause mortality to December 31, 2003. Fitness was quantified by maximal treadmill exercise test and was categorized for analysis as low, moderate, and high performance. Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals.
Overall, the multivariable-adjusted hazard ratios and 95% confidence intervals for mortality across incremental fitness categories were 1.00 (reference), 0.45 (0.30-0.68) and 0.35 (0.22-0.53), linear trend P < .01 for all-cause, 0.50 (0.23-1.10) and 0.29 (0.12-0.71), linear trend P = .02 for cardiovascular disease, and 0.38 (0.20-0.74) and 0.40 (0.20-0.80), linear trend P = .01 for cancer mortality.
Among men with musculoskeletal conditions, higher fitness is associated with lower risk of death by cardiovascular disease, cancer, or any cause, independent of other risk factors.
本研究旨在探讨心肺适能与肌肉骨骼疾病男性患者心血管疾病、癌症和全因死亡率之间的关联。
本研究纳入了 12728 名患有肌肉骨骼疾病（包括关节疼痛、腰痛、关节僵硬、关节炎、骨质疏松症或痛风）的男性患者，其平均年龄为 47.0（9.3）岁，随访终点为 2003 年 12 月 31 日，随访期间记录全因死亡率。心肺适能通过最大跑步机运动测试进行量化，并分为低、中、高三个表现等级进行分析。采用 Cox 比例风险回归模型计算风险比及其 95%置信区间。
总体而言，按递增心肺适能等级分层后，多变量校正的死亡率风险比及其 95%置信区间分别为 1.00（参考）、0.45（0.30-0.68）和 0.35（0.22-0.53），全因死亡率线性趋势 P <.01；心血管疾病死亡率风险比及其 95%置信区间分别为 0.50（0.23-1.10）和 0.29（0.12-0.71），线性趋势 P =.02；癌症死亡率风险比及其 95%置信区间分别为 0.38（0.20-0.74）和 0.40（0.20-0.80），线性趋势 P =.01。
在患有肌肉骨骼疾病的男性中，较高的心肺适能与较低的心血管疾病、癌症或任何原因死亡风险相关，且独立于其他风险因素。
