• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

佩内洛普/普里莫-临床加速器计算的光子和电子能谱。

PENELOPE/PRIMO-calculated photon and electron spectra from clinical accelerators.

机构信息

West German Proton Therapy Centre Essen (WPE), Essen, D-45147, Germany.

West German Cancer Center (WTZ), Essen, D-45147, Germany.

出版信息

Radiat Oncol. 2019 Jan 11;14(1):6. doi: 10.1186/s13014-018-1186-8.

DOI:10.1186/s13014-018-1186-8
PMID:30634994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330451/
Abstract

BACKGROUND

The availability of photon and electron spectra in digital form from current accelerators and Monte Carlo (MC) systems is scarce, and one of the packages widely used refers to linacs with a reduced clinical use nowadays. Such spectra are mainly intended for the MC calculation of detector-related quantities in conventional broad beams, where the use of detailed phase-space files (PSFs) is less critical than for MC-based treatment planning applications, but unlike PSFs, spectra can easily be transferred to other computer systems and users.

METHODS

A set of spectra for a range of Varian linacs has been calculated using the PENELOPE/PRIMO MC system. They have been extracted from PSFs tallied for field sizes of 10 cm × 10 cm and 15 cm × 15 cm for photon and electron beams, respectively. The influence of the spectral bin width and of the beam central axis region used to extract the spectra have been analyzed.

RESULTS

Spectra have been compared to those by other authors showing good agreement with those obtained using the, now superseded, EGS4/BEAM MC code, but significant differences with the most widely used photon data set. Other spectra, particularly for electron beams, have not been published previously for the machines simulated in this work. The influence of the bin width on the spectrum mean energy for 6 and 10 MV beams has been found to be negligible. The size of the region used to extract the spectra yields differences of up to 40% for the mean energies in 10 MV beams, but the maximum difference for TPR values derived from depth-dose distributions does not exceed 2% relative to those obtained using the PSFs. This corresponds to k differences below 0.2% for a typical Farmer-type chamber, considered to be negligible for reference dosimetry. Different configurations for using electron spectra have been compared for 6 MeV beams, concluding that the geometry used for tallying the PSFs used to extract the spectra must be accounted for in subsequent calculations using the spectra as a source.

CONCLUSIONS

An up-to-date set of consistent spectra for Varian accelerators suitable for the calculation of detector-related quantities in conventional broad beams has been developed and made available in digital form.

摘要

背景

当前加速器和蒙特卡罗(MC)系统提供的光子和电子能谱以数字形式呈现的情况较为少见,其中一个广泛使用的软件包是指现在临床应用较少的直线加速器。这些能谱主要用于传统宽束中与探测器相关的量的 MC 计算,在这种情况下,详细的相空间文件(PSF)的使用不如 MC 治疗计划应用程序那么关键,但与 PSF 不同的是,能谱可以轻松地转移到其他计算机系统和用户。

方法

使用 PENELPE/PRIMO MC 系统为一系列瓦里安直线加速器计算了一套能谱。它们是从光子和电子束的 10cm×10cm 和 15cm×15cm 射野的 PSF 中提取出来的。分析了光谱-bin 宽度和用于提取光谱的束中轴线区域的影响。

结果

与其他作者的能谱进行了比较,结果与使用现已过时的 EGS4/BEAM MC 代码获得的能谱吻合良好,但与最广泛使用的光子数据集存在显著差异。对于在这项工作中模拟的机器,其他的能谱,特别是电子束的能谱,以前没有发表过。对于 6MV 和 10MV 束,发现光谱平均能量对 bin 宽度的影响可以忽略不计。用于提取光谱的区域大小会导致 10MV 束平均能量的差异高达 40%,但从深度剂量分布得出的 TPR 值的最大差异相对于使用 PSF 获得的值不超过 2%。这对应于典型的 Farmer 型剂量计的 k 差异低于 0.2%,对于参考剂量学来说可以忽略不计。对于 6MV 束,比较了使用电子能谱的不同配置,得出结论:必须考虑用于提取光谱的 PSF 计数的几何形状,以便在后续使用能谱作为源的计算中进行考虑。

结论

开发了一套适用于传统宽束中与探测器相关的量的 MC 计算的瓦里安加速器的最新、一致的能谱,并以数字形式提供。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/ffacff76112d/13014_2018_1186_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/86a40aa23311/13014_2018_1186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/dc78f5d116ee/13014_2018_1186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/616623f15d99/13014_2018_1186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/ff65252fe857/13014_2018_1186_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/15d0d3e8327f/13014_2018_1186_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/d968db990207/13014_2018_1186_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/ffacff76112d/13014_2018_1186_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/86a40aa23311/13014_2018_1186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/dc78f5d116ee/13014_2018_1186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/616623f15d99/13014_2018_1186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/ff65252fe857/13014_2018_1186_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/15d0d3e8327f/13014_2018_1186_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/d968db990207/13014_2018_1186_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43a1/6330451/ffacff76112d/13014_2018_1186_Fig7_HTML.jpg

相似文献

1
PENELOPE/PRIMO-calculated photon and electron spectra from clinical accelerators.佩内洛普/普里莫-临床加速器计算的光子和电子能谱。
Radiat Oncol. 2019 Jan 11;14(1):6. doi: 10.1186/s13014-018-1186-8.
2
MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO).从静态场到 VMAT 计划的 MLC 参数:在专用 RT 的 MC 环境(PRIMO)中的评估。
Radiat Oncol. 2019 Dec 2;14(1):216. doi: 10.1186/s13014-019-1421-y.
3
Output correction factors for nine small field detectors in 6 MV radiation therapy photon beams: a PENELOPE Monte Carlo study.6兆伏放射治疗光子束中九个小场探测器的输出校正因子:一项PENELOPE蒙特卡罗研究
Med Phys. 2014 Apr;41(4):041711. doi: 10.1118/1.4868695.
4
Comparison of measured electron energy spectra for six matched, radiotherapy accelerators.六台匹配的放射治疗加速器测量的电子能谱比较。
J Appl Clin Med Phys. 2018 May;19(3):183-192. doi: 10.1002/acm2.12317. Epub 2018 Mar 30.
5
A fast GPU-accelerated Monte Carlo engine for calculation of MLC-collimated electron fields.一种快速 GPU 加速的蒙特卡罗引擎,用于计算 MLC 准直电子场。
Med Phys. 2023 Jan;50(1):600-618. doi: 10.1002/mp.15938. Epub 2022 Aug 31.
6
Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs.西门子和瓦里安直线加速器高能光子束的光核剂量计算。
Med Phys. 2003 Aug;30(8):1990-2000. doi: 10.1118/1.1590436.
7
PRIMO Monte Carlo software benchmarked against a reference dosimetry dataset for 6 MV photon beams from Varian linacs.PRIMO 蒙特卡罗软件针对瓦里安直线加速器 6 MV 光子束的参考剂量数据集进行了基准测试。
Radiat Oncol. 2018 Aug 7;13(1):144. doi: 10.1186/s13014-018-1076-0.
8
Evaluation of latent variances in Monte Carlo dose calculations with Varian TrueBeam photon phase-spaces used as a particle source.使用瓦里安 TrueBeam 光子相位空间作为粒子源,评估蒙特卡罗剂量计算中的潜在方差。
Phys Med Biol. 2017 Dec 29;63(1):01NT03. doi: 10.1088/1361-6560/aa9f39.
9
Monte Carlo dose calculation improvements for low energy electron beams using eMC.利用 eMC 提高低能电子束的蒙特卡罗剂量计算精度。
Phys Med Biol. 2010 Aug 21;55(16):4577-88. doi: 10.1088/0031-9155/55/16/S11. Epub 2010 Jul 29.
10
Monte Carlo simulation of MOSFET detectors for high-energy photon beams using the PENELOPE code.使用PENELOPE代码对用于高能光子束的MOSFET探测器进行蒙特卡罗模拟。
Phys Med Biol. 2007 Jan 7;52(1):303-16. doi: 10.1088/0031-9155/52/1/020. Epub 2006 Dec 20.

引用本文的文献

1
An Investigation of the Dosimetric Uncertainties in the myOSLchip System: The Impact of Contributing Factors on Measurement Accuracy.myOSLchip 系统剂量学不确定性研究:影响因素对测量准确性的影响
Cureus. 2025 Jul 18;17(7):e88239. doi: 10.7759/cureus.88239. eCollection 2025 Jul.
2
Microdosimetric Simulation of Gold-Nanoparticle-Enhanced Radiotherapy.金纳米颗粒增强放射治疗的微剂量模拟。
Int J Mol Sci. 2024 Sep 2;25(17):9525. doi: 10.3390/ijms25179525.
3
Validation of an in vivo transit dosimetry algorithm using Monte Carlo simulations and ionization chamber measurements.

本文引用的文献

1
Dosimetry of small static fields used in external photon beam radiotherapy: Summary of TRS-483, the IAEA-AAPM international Code of Practice for reference and relative dose determination.外照射光子束放射治疗中应用的小静态场剂量学:IAEA-AAPM 国际实践导则 TRS-483 的摘要,用于参考和相对剂量确定。
Med Phys. 2018 Nov;45(11):e1123-e1145. doi: 10.1002/mp.13208. Epub 2018 Oct 17.
2
Impact of new ICRU Report 90 recommendations on calculated correction factors for reference dosimetry.新 ICRU 报告 90 号建议对参考剂量计算校正因子的影响。
Phys Med Biol. 2018 Aug 1;63(15):155015. doi: 10.1088/1361-6560/aad148.
3
Monte Carlo simulations in radiotherapy dosimetry.
使用蒙特卡罗模拟和电离室测量验证体内传输剂量算法。
J Appl Clin Med Phys. 2024 Feb;25(2):e14187. doi: 10.1002/acm2.14187. Epub 2023 Oct 27.
4
Comparison of PRIMO Monte Carlo code and Eclipse treatment planning system in calculation of dosimetric parameters in brain cancer radiotherapy.PRIMO蒙特卡罗代码与Eclipse治疗计划系统在脑癌放射治疗剂量学参数计算中的比较
Rep Pract Oncol Radiother. 2022 Oct 31;27(5):863-874. doi: 10.5603/RPOR.a2022.0091. eCollection 2022.
5
Monte Carlo Calculation of the Energy Spectrum of a 6 MeV Electron Beam using PENetration and Energy Loss of Positrons and Electrons Code.使用正电子和电子的穿透与能量损失代码对6兆电子伏特电子束能谱进行蒙特卡罗计算。
J Med Phys. 2020 Apr-Jun;45(2):116-122. doi: 10.4103/jmp.JMP_104_19. Epub 2020 Jul 20.
放射治疗剂量学中的蒙特卡罗模拟。
Radiat Oncol. 2018 Jun 27;13(1):121. doi: 10.1186/s13014-018-1065-3.
4
The physics of small megavoltage photon beam dosimetry.小兆伏光子束剂量学的物理原理。
Radiother Oncol. 2018 Feb;126(2):205-213. doi: 10.1016/j.radonc.2017.11.001. Epub 2017 Nov 30.
5
A geometrical model for the Monte Carlo simulation of the TrueBeam linac.用于TrueBeam直线加速器蒙特卡罗模拟的几何模型。
Phys Med Biol. 2015 Jun 7;60(11):N219-29. doi: 10.1088/0031-9155/60/11/N219. Epub 2015 May 18.
6
Addendum to the AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon beams.美国医学物理师协会(AAPM)高能光子束临床参考剂量测定TG-51协议补遗
Med Phys. 2014 Apr;41(4):041501. doi: 10.1118/1.4866223.
7
PRIMO: a graphical environment for the Monte Carlo simulation of Varian and Elekta linacs.PRIMO:用于瓦里安和医科达直线加速器的蒙特卡罗模拟的图形环境。
Strahlenther Onkol. 2013 Oct;189(10):881-6. doi: 10.1007/s00066-013-0415-1. Epub 2013 Sep 6.
8
A combined approach of variance-reduction techniques for the efficient Monte Carlo simulation of linacs.采用变分减小技术的组合方法,可实现直线加速器的高效蒙特卡罗模拟。
Phys Med Biol. 2012 May 21;57(10):3013-24. doi: 10.1088/0031-9155/57/10/3013. Epub 2012 Apr 26.
9
A PENELOPE-based system for the automated Monte Carlo simulation of clinacs and voxelized geometries-application to far-from-axis fields.基于 PENELOPE 的临床和体素化几何自动蒙特卡罗模拟系统——远轴场的应用。
Med Phys. 2011 Nov;38(11):5887-95. doi: 10.1118/1.3643029.
10
PENLINAC: extending the capabilities of the Monte Carlo code PENELOPE for the simulation of therapeutic beams.PENLINAC:扩展蒙特卡罗代码PENELOPE用于治疗束模拟的功能。
Phys Med Biol. 2008 Sep 7;53(17):4573-93. doi: 10.1088/0031-9155/53/17/008. Epub 2008 Aug 4.