Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Department of Biomedical Sciences and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.
Sci Rep. 2019 Jan 11;9(1):57. doi: 10.1038/s41598-018-37312-0.
Object recognition tasks detect cognitive deficits in transgenic Alzheimer's disease (AD) mouse models. Object recognition, however, is not a unitary process, and there are many uncharacterized facets of object processing with relevance to AD. We therefore systematically evaluated object processing in 5xFAD and 3xTG AD mice to clarify the nature of object recognition-related deficits. Twelve-month-old male and female 5xFAD and 3xTG mice were assessed on tasks for object identity recognition, spatial recognition, and multisensory object perception. Memory and multisensory perceptual impairments were observed, with interesting dissociations between transgenic AD strains and sex that paralleled neuropathological changes. Overreliance on the widespread "object recognition" task threatens to slow discovery of potentially significant and clinically relevant behavioural effects related to this multifaceted cognitive function. The current results support the use of carefully designed object-based test batteries to clarify the relationship between "object recognition" impairments and specific aspects of AD pathology in rodent models.
物体识别任务可检测转 AD 基因（Alzheimer's disease）小鼠模型的认知缺陷。然而，物体识别并不是一个单一的过程，还有许多与 AD 相关的未被描述的物体处理方面。因此，我们系统地评估了 5xFAD 和 3xTG AD 小鼠的物体处理，以阐明与物体识别相关的缺陷的性质。对 12 个月大的雄性和雌性 5xFAD 和 3xTG 小鼠进行了物体身份识别、空间识别和多感官物体感知任务的评估。记忆和多感官感知障碍被观察到，与神经病理学变化相平行的是转 AD 株系和性别的有趣分离。对广泛应用的“物体识别”任务的过度依赖，可能会减缓与这一多方面认知功能相关的潜在重要和临床相关行为效应的发现。目前的结果支持使用精心设计的基于物体的测试组合，以阐明“物体识别”损伤与啮齿动物模型中 AD 病理的特定方面之间的关系。
