Institute of Physiology, University of Regensburg, Regensburg, Germany,
Nephron. 2019;141(4):265-272. doi: 10.1159/000496278. Epub 2019 Jan 11.
The healthy kidney is considered to be a relatively stable organ with little baseline cell turnover. Nevertheless, cells are constantly replaced to conserve the structural and functional integrity of the organ. The mechanisms of the baseline regenerative processes may also be relevant in situations of insults to the kidney, when the need for cellular replacement considerable exceeds the baseline cell turnover. This review will focus on the mechanisms of the regeneration of the tubular system, in particular the proximal tubule. Specifically, we will cover new aspects of (i), the regenerative capacity of the proximal tubule in health and disease, (ii) the relevant cell populations of proximal tubular regeneration, and (iii) the supportive role of renal interstitial cells in regenerative processes of the tubular system.
健康的肾脏被认为是一个相对稳定的器官，其细胞基础更新率较低。然而，细胞在不断被替换，以维持器官的结构和功能完整性。在肾脏受到损伤的情况下，当细胞替换的需求大大超过基础细胞更新率时，这些基础再生过程的机制可能也具有重要意义。本综述将重点关注管状系统（特别是近端小管）的再生机制。具体来说，我们将涵盖以下几个方面：（i）健康和疾病状态下近端小管的再生能力；（ii）近端肾小管再生的相关细胞群体；以及（iii）肾间质细胞在管状系统再生过程中的支持作用。
