Faculty of Science , Siedlce University of Natural Sciences and Humanities , Siedlce , Poland.
Hospital Pharmacy Department , Hospital Solec Sp. z o. o. , Warszawa , Poland.
Crit Rev Anal Chem. 2019;49(5):395-402. doi: 10.1080/10408347.2018.1537120. Epub 2019 Jan 12.
The paper collates and summarizes information on stilbene derivatives, i.e. (E)-azastilbenes, taking into account the new possibilities of their applications, inter alia, in the natural environment. (E)-azastilbenes are biologically active, which is of great importance to humans and the whole ecosystem. As evidenced by a number of studies, they show fungistatic, fungitoxic and, depending on the concentration, estrogenic properties. Due to their properties, (E)-azastilbenes are still of great interest to researchers, who have high hopes for their pharmacological use or the possibility of using them as antiseptics, disinfectants, or preservatives in various products, including the environmental ones. Because of the difficulties with their determination, the study assumes optimal conditions of (E)-azastilbenes extraction from environmental samples and the technique of isotachophoresis is employed for the first time in this type of analysis. The highest recovery values ranging from 83 to 97% were obtained on the aryl extraction columns. The range of linearity of the developed method on the naphthylpropyl column ranged from 5 to 300 µg/mL.
本文综述了二苯乙烯衍生物(E)-亚肉桂基苯,考虑到其在自然环境中的新应用可能性,(E)-亚肉桂基苯具有生物活性,这对人类和整个生态系统都非常重要。有多项研究表明,它们具有抑菌、杀菌作用,并且根据浓度的不同,还具有雌激素特性。由于其特性,(E)-亚肉桂基苯仍然受到研究人员的极大关注,他们对其在药理学上的应用或作为防腐剂、消毒剂或在各种产品中的防腐剂的可能性寄予厚望,包括环境产品。由于其测定存在困难,本研究假设从环境样品中提取(E)-亚肉桂基苯的最佳条件,并首次在这种类型的分析中采用等速电泳技术。在芳基萃取柱上获得了 83%至 97%的最高回收率值。在萘丙基柱上开发的方法的线性范围为 5 至 300μg/mL。