Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Pharm Des. 2018;24(39):4675-4680. doi: 10.2174/1381612825666190111144525.
Small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as proliferation, apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world with an estimated 9.6 million deaths in 2018. So, early diagnosis of cancer is critical for successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for the detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor cancer biomarker is required. In this review, we have highlighted recent advances in biosensors for circulating miRNA detection.
小的非编码 microRNAs（miRNAs）被认为是各种癌症早期检测的非侵入性生物标志物。事实上，miRNAs 在致癌过程中起着关键作用，如增殖、凋亡和转移。心血管疾病之后，癌症是世界上的第二大致死原因，2018 年估计有 960 万人死亡。因此，癌症的早期诊断对成功治疗至关重要。迄今为止，已经应用了几种选择性和灵敏的基于实验室的方法来检测循环 miRNA，但需要一种简单、短的检测时间和低成本的方法，如生物传感器方法作为监测癌症生物标志物的替代方法。在这篇综述中，我们强调了用于检测循环 miRNA 的生物传感器的最新进展。
