Puthenveettil Nitu, Rajan Sunil, Mohan Anish, Paul Jerry, Kumar Lakshmi
Department of Anaesthesiology and Critical Care, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Indian J Anaesth. 2018 Dec;62(12):972-977. doi: 10.4103/ija.IJA_443_18.
Post-dural puncture headache (PDPH) is a consequence of spinal and epidural anaesthesia in approximately 1% of obstetric patients. The gold standard for its treatment is epidural blood patch. Sphenopalatine ganglion block (SPGB) has been proposed as a non-invasive intervention with minimal adverse effect. The primary objective of this study was to assess the efficacy of SPGB for treatment of PDPH. Secondary objectives were to assess onset of analgesia, duration of block and adverse effects.
Twenty parturients diagnosed to have PDPH, resistant to standard treatment modalities such as intravenous fluids, abdominal binder, bed rest and caffeine, were recruited into this prospective observational study. Patients were allocated to either of the two groups. Group A patients received paracetamol 1 g 8 hourly intravenously for a day. If adequate pain relief was not achieved, diclofenac 75 mg 12 hourly was added. Patients in group B received SPGB with 2% lignocaine. Fisher's exact test, Mann-Whitney test and independent sample -test were used for statistical analysis.
About 88.89% patients in group B had adequate pain relief within 5 min of block ( < 0.001). Pain was significantly lower in Group B for up to 8 h, with no adverse effects.
SPGB is an effective initial modality for managing severe headache in patients with PDPH.
硬膜穿刺后头痛(PDPH)是约1%产科患者脊髓及硬膜外麻醉后的并发症。其治疗的金标准是硬膜外血补丁。蝶腭神经节阻滞(SPGB)已被提议作为一种不良反应最小的非侵入性干预措施。本研究的主要目的是评估SPGB治疗PDPH的疗效。次要目的是评估镇痛起效时间、阻滞持续时间及不良反应。
20例诊断为PDPH且对静脉输液、腹部束带、卧床休息及咖啡因等标准治疗方式无效的产妇被纳入这项前瞻性观察研究。患者被分配到两组中的一组。A组患者静脉注射对乙酰氨基酚1g,每8小时一次,共一天。若未实现充分的疼痛缓解,则每12小时加用双氯芬酸75mg。B组患者接受2%利多卡因的SPGB治疗。采用Fisher精确检验、Mann-Whitney检验和独立样本检验进行统计分析。
B组约88.89%的患者在阻滞5分钟内实现了充分的疼痛缓解(P<0.001)。B组疼痛在长达8小时内显著更低,且无不良反应。
SPGB是管理PDPH患者严重头痛的一种有效初始方式。