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本文引用的文献

1
Evaluation of Isosorbide Mononitrate for Preinduction of Cervical Ripening: A Randomized Placebo-Controlled Trial.单硝酸异山梨酯用于引产促宫颈成熟的评估：一项随机安慰剂对照试验
J Family Reprod Health. 2015 Jun;9(2):75-81.
2
The impact of isosorbide mononitrate on cervical ripening and labor induction in primiparous women with term pregnancy: A double-blind, randomized, controlled trial.单硝酸异山梨酯对足月妊娠初产妇宫颈成熟及引产的影响：一项双盲、随机、对照试验。
Iran J Nurs Midwifery Res. 2013 May;18(3):246-50.
3
Induction of labor versus expectant management for pregnancies beyond 41 weeks.41周以上妊娠的引产与期待治疗
J Matern Fetal Neonatal Med. 2014 Jan;27(2):173-6. doi: 10.3109/14767058.2013.806892. Epub 2013 Jun 20.
4
The pharmacology of prostaglandins for induction of labor.前列腺素在引产中的药理学。
J Midwifery Womens Health. 2013 Mar-Apr;58(2):133-44; quiz 238-9. doi: 10.1111/jmwh.12022.
5
Induction of labour in postdates pregnant women.
J Coll Physicians Surg Pak. 2012 Oct;22(10):644-7. doi: 10.2012/JCPSP.644647.
6
Delivery outcomes in women undergoing elective labor induction at term.足月选择性引产的产妇分娩结局。
Arch Gynecol Obstet. 2013 Mar;287(3):407-11. doi: 10.1007/s00404-012-2582-1. Epub 2012 Oct 5.
7
Current pharmacotherapy options for labor induction.目前用于引产的药物治疗选择。
Expert Opin Pharmacother. 2012 Oct;13(14):2005-14. doi: 10.1517/14656566.2012.722622.
8
Evaluation of isosorbide mononitrate for cervical ripening prior to induction of labor for postdated pregnancy in an outpatient setting.门诊条件下，评估单硝酸异山梨酯用于过期妊娠引产时的宫颈成熟度。
Int J Gynaecol Obstet. 2012 Sep;118(3):205-9. doi: 10.1016/j.ijgo.2012.04.017. Epub 2012 Jun 20.
9
Outpatient vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening and labor induction postterm: a randomized controlled study.门诊阴道给予一氧化氮供体单硝酸异山梨酯用于过期妊娠宫颈成熟和引产：一项随机对照研究。
Am J Obstet Gynecol. 2007 Jan;196(1):50.e1-5. doi: 10.1016/j.ajog.2006.08.034.
10
Intravaginal misoprostol vs. dinoprostone as cervical ripening and labor-inducing agents.
Int J Gynaecol Obstet. 2004 Jun;85(3):285-6. doi: 10.1016/j.ijgo.2003.11.016.

硝酸甘油安慰剂经阴道给药对过期妊娠引产前宫颈成熟的影响的比较随机研究。

A comparative randomized study on effect of vaginally administered glyceryl trinitrate placebo on cervical ripening prior to induction of labor in overdue pregnancies.

机构信息

Deparment of Gynecology and Obstetrics, Süleymaniye Education and Research Hospital, Istanbul, Turkey.

Deparment of Gynecology and Obstetrics, Istanbul Aydin University, Istanbul, Turkey.

出版信息

Indian J Pharmacol. 2018 Sep-Oct;50(5):260-265. doi: 10.4103/ijp.IJP_182_18.

DOI:10.4103/ijp.IJP_182_18
PMID:30636829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6302700/
Abstract

OBJECTIVE

The aim of this study is to examine the effectiveness and adverse effects of local glyceryl trinitrate (GTN) application during labor compared with a placebo group.

METHODS

The study consisted of 70 pregnant women with overdue pregnancies who presented to the hospital for labor induction between January 2009 and January 2011 in the Obstetrics Clinic of Istanbul Süleymaniye Gynecology and Obstetrics Education and Training Hospital. Vaginal suppositories-containing GTN (36/70) or placebo (34/70) was administered to the participants in a randomized fashion. The placebo and GTN involving vaginal ovules used in the study were prepared in the Pharmacy Department of Istanbul University Faculty of Pharmacy. Maternal effects during labor, rates of normal vaginal and C/S deliveries, the interval between the initial medication and delivery, and amount of total oxytocin used were compared between the GTN and placebo groups.

RESULTS

There were no significant differences between the GTN and placebo groups regarding bishop scores, the interval between medication and delivery, delivery types, indications for cesarean section, and complications including hyperstimulation, tachysystole, uterine rupture, placental abruption, and uterine atony ( > 0.05).

CONCLUSION

Our results revealed that there were no differences between GTN and placebo regarding their effect on cervical ripening in overdue pregnant women.

摘要

目的

本研究旨在比较局部甘油三硝酸酯（GTN）在分娩时的应用与安慰剂组的效果和不良反应。

方法

本研究纳入了 2009 年 1 月至 2011 年 1 月期间在伊斯坦布尔 Süleymaniye 妇产科教育和培训医院妇产科诊所因过期妊娠而入院引产的 70 名孕妇。采用随机方法向参与者阴道内给予含有 GTN（36/70）或安慰剂（34/70）的阴道栓剂。研究中使用的 GTN 涉及的安慰剂和阴道栓剂均由伊斯坦布尔大学药学院药剂科制备。比较 GTN 组和安慰剂组的产妇在分娩过程中的效果、阴道分娩和剖宫产的比例、初始用药与分娩的间隔时间以及催产素的总用量。

结果

GTN 组和安慰剂组在 Bischof 评分、用药与分娩的间隔时间、分娩类型、剖宫产指征以及包括过度刺激、心动过速、子宫破裂、胎盘早剥和子宫乏力在内的并发症方面无显著差异（>0.05）。

结论

我们的结果表明，在过期妊娠孕妇的宫颈成熟方面，GTN 和安慰剂的效果没有差异。