Sadeghian Mohammad Hadi, Rezaei Dezaki Zahra
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Pathol. 2018 Summer;13(3):294-300. Epub 2018 Sep 12.
Acute myeloid leukemia (AML) as a distortion of blood cells involves the differ entiation of hematopoietic stem cells. Several studies established the irregular over expression of specific genes is a common finding in patients with AML. The ectopic viral integration site-1 () gene is a protooncogene subject to alternative splicing, and encodes a zincfinger protein that acts as a transcriptional regulator in early devel opment. Forced overexpression of in hematopoietic progenitors later induced a myeloid differentiation block. The current review aimed at determining the prognos tic value of expression in patients with AML in the age range of one month to fifteen years. The scientific databases including PubMed, Google Scholar, EMBASE, Scopus, and ISI published up to January 2016 were searched using the conformity keywords and a total of four articles were studied. Three articles declared higher overexpression of in patients with mixed-lineage leukemia (MLL) rearrangements. The percentage of overall survival (OS), reported in two articles, decreased in AML patients with high EVI1 expression. A study reported that the relationship between EVI1 expression and OS was negligible in cases with and without expression. Another study showed significant differences in event free survival (EFS) and OS in the group of patients with positive MLL-AF9 between + and patients. The current study revealed that high expression was not a poor prognostic factor in pediatric patients with AML. And this gene expression was mainly prognostic concomitantly by other factors such as MLL rearrangement, expression, and white blood cell (WBC) count.
急性髓系白血病（AML）作为血细胞的一种畸变，涉及造血干细胞的分化。多项研究表明，特定基因的异常过表达在AML患者中是常见现象。异位病毒整合位点-1（EVI1）基因是一种原癌基因，可进行可变剪接，并编码一种锌指蛋白，该蛋白在早期发育中作为转录调节因子发挥作用。在造血祖细胞中强制过表达EVI1后来会诱导髓系分化阻滞。本综述旨在确定EVI1表达在1个月至15岁AML患者中的预后价值。使用符合要求的关键词检索了包括PubMed、谷歌学术、EMBASE、Scopus和ISI在内的科学数据库，截至2016年1月共研究了4篇文章。3篇文章宣称在混合谱系白血病（MLL）重排患者中EVI1过表达更高。两篇文章报道，EVI1高表达的AML患者总生存率（OS）降低。一项研究报告称，在有或无EVI1表达的病例中，EVI1表达与OS之间的关系可忽略不计。另一项研究表明，MLL-AF9阳性患者组中，EVI1阳性和阴性患者在无事件生存期（EFS）和OS方面存在显著差异。当前研究表明，高EVI1表达在儿童AML患者中并非不良预后因素。而且该基因表达主要与其他因素如MLL重排、EVI1表达和白细胞（WBC）计数共同作为预后指标。
