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口服阿司匹林诱发的库尼综合征:病例报告及文献综述

Kounis syndrome induced by oral intake of aspirin: case report and literature review.

作者信息

Hangouche Abdelkader Jalil El, Lamliki Ouiame, Oukerraj Latifa, Dakka Taoufiq, Doghmi Nawal, Zarzur Jamila, Cherti Mohammed

机构信息

Department of Cardiology B, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

Exercise Physiology and Autonomic Nervous System Team "EPE-SNA", Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.

出版信息

Pan Afr Med J. 2018 Aug 30;30:301. doi: 10.11604/pamj.2018.30.301.14948. eCollection 2018.

Abstract

The Kounis-Zavras syndrome is defined as the coincidental occurrence of acute coronary events and hypersensitivity reactions following an allergic reaction including a mast-cell degranulation of vasospastic mediators. This report describes a case of Kounis-Zavras syndrome in the setting of aspirin-induced asthma also known as Samter-Beer triad combining nasal polyps, asthma, and aspirin allergy leading to vasospasm and myocardial infarction. All physicians should be aware of The Kounis syndrome and always keep that unique clinical entity in mind to recognize it promptly and direct the therapy at suppressing the allergic reaction.

摘要

库尼斯-扎夫拉斯综合征定义为急性冠脉事件与过敏反应(包括血管痉挛介质的肥大细胞脱颗粒)后发生的超敏反应同时出现。本报告描述了一例阿司匹林诱发哮喘(又称桑特-比尔三联征,合并鼻息肉、哮喘和阿司匹林过敏,导致血管痉挛和心肌梗死)背景下的库尼斯-扎夫拉斯综合征病例。所有医生都应了解库尼斯综合征,并始终牢记这一独特的临床实体,以便及时识别并指导治疗以抑制过敏反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c5/6320451/739301881039/PAMJ-30-301-g002.jpg

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