Jia Fumin, Wagle Shukla Aparna, Hu Wei, Almeida Leonardo, Holanda Vanessa, Zhang Jianguo, Meng Fangang, Okun Michael S, Li Luming
National Engineering laboratory for Neuromodulation Tsinghua University Beijing China.
University of Florida Center for Movement Disorders and Neurorestoration Gainesville FL USA.
Mov Disord Clin Pract. 2018 Oct 1;5(5):538-541. doi: 10.1002/mdc3.12658. eCollection 2018 Sep-Oct.
Deep brain stimulation (DBS) with high frequency (HFS) is a well-established therapy for Parkinson's disease (PD); however, low frequency DBS (LFS) may control axial symptoms including freezing of gait (FOG). We conducted a pilot safety and feasibility study to examine if a novel DBS paradigm of variable frequency stimulation (VFS) that combined HFS and LFS would capture a broader set of motor symptoms.
Four PD patients with bilateral STN DBS and FOG were enrolled. A UPDRS III and 10 m timed up and go (TUG) task were performed off medications-off DBS and then one hour after HFS and one hour after VFS programming.
The UPDRS III motor score improved by additional 14% during VFS setting when compared to HFS. VFS also increased gait speed (mean change 45%) and reduced the number of freezing episodes (mean change 58%).
VFS improves UPDRS and FOG in PD when compared to HFS.Copyright © 2018 International Parkinson and Movement Disorder Society.
高频深部脑刺激（DBS）是治疗帕金森病（PD）的一种成熟疗法；然而，低频DBS（LFS）可能控制包括步态冻结（FOG）在内的轴性症状。我们开展了一项初步安全性和可行性研究，以检验一种将高频刺激（HFS）和低频刺激相结合的新型可变频率刺激（VFS）DBS模式是否能控制更广泛的运动症状。
招募了4例双侧丘脑底核DBS且有FOG的PD患者。在关药-关DBS状态下，以及在HFS编程后1小时和VFS编程后1小时进行统一帕金森病评定量表第三部分（UPDRS III）和10米计时起立行走（TUG）任务。
与HFS相比，VFS设置期间UPDRS III运动评分额外提高了14%。VFS还提高了步态速度（平均变化45%），并减少了冻结发作次数（平均变化58%）。
与HFS相比，VFS可改善PD患者的UPDRS和FOG。版权所有©2018国际帕金森病和运动障碍协会。
