Egloff Christian, Huber Lukas, Wurm Markus, Pagenstert Geert
Department of Orthopedics and Traumatology, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Arch Orthop Trauma Surg. 2019 Jun;139(6):807-816. doi: 10.1007/s00402-019-03117-7. Epub 2019 Jan 14.
To evaluate the diagnostic and clinical value of SPECT/CT compared to the standard algorithm for patients with persistent symptoms after anterior cruciate ligament reconstructions. The standard algorithm uses clinical information, conventional radiographs, MRI and CT scan, while the trial algorithm uses the same information but SPECT/CT in addition.
In a diagnostic comparative trial three experienced surgeons evaluated 23 consecutive patients with persistent symptoms after ACL reconstruction using first standard and second the trial algorithm with a time interval. Each rater had to establish a diagnosis and therapeutic decision with each algorithm. On MRI, graft continuity, bone marrow edema, chondral and meniscal lesions, femoral notch osteophytes were evaluated. Bone tracer uptake in SPECT/CT was anatomically analyzed and compared with MRI findings. MRI findings and SPECT/CT tracer uptake were correlated using Spearman's rho test.
Additional SPECT/CT analysis did not change diagnosis in any case and did not correlate with clinical graft integrity. Treatment decisions remained unchanged as well. Chondral lesions, arthritic changes, meniscal lesions, graft impingement are best visualized in MRI and showed correspondent tracer uptake in SPECT/CT. Tunnel position was well classified with standard CT scan and showed no correlation with SPECT/CT tracer uptake.
Information derived by SPECT/CT in addition to the standard algorithm using clinical information, X-rays, MRI, and CT scan did not change the diagnosis or treatment plan. There is currently no justification to implement SPECT/CT for patients with persistent symptoms after anterior cruciate ligament reconstructions.
Level II: diagnostic comparative study.
评估与标准算法相比,SPECT/CT对前交叉韧带重建术后仍有持续症状患者的诊断及临床价值。标准算法使用临床信息、传统X线片、MRI和CT扫描,而试验算法除使用相同信息外,还增加了SPECT/CT。
在一项诊断性对比试验中,三名经验丰富的外科医生首先使用标准算法,然后在间隔一段时间后使用试验算法,对23例前交叉韧带重建术后仍有持续症状的患者进行评估。每位评估者必须根据每种算法做出诊断和治疗决策。在MRI上,评估移植物的连续性、骨髓水肿、软骨和半月板损伤、股骨髁间窝骨赘。对SPECT/CT中的骨显像剂摄取情况进行解剖学分析,并与MRI结果进行比较。使用Spearman等级相关检验对MRI结果和SPECT/CT显像剂摄取情况进行相关性分析。
额外的SPECT/CT分析在任何情况下均未改变诊断,且与临床移植物完整性无关。治疗决策也保持不变。软骨损伤、关节炎改变、半月板损伤、移植物撞击在MRI上显示最佳,且在SPECT/CT上显示相应的显像剂摄取。隧道位置通过标准CT扫描能很好地分类,且与SPECT/CT显像剂摄取无关。
除使用临床信息、X线、MRI和CT扫描的标准算法外,SPECT/CT提供的信息并未改变诊断或治疗方案。目前,对于前交叉韧带重建术后仍有持续症状的患者,没有理由采用SPECT/CT。
二级:诊断性对比研究。