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母乳喂养与 2 型糖尿病:系统评价和荟萃分析。

Breastfeeding and Type 2 Diabetes: Systematic Review and Meta-Analysis.

机构信息

Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Rua Marechal Deodoro 1160 - 3° andar, Pelotas, 96020-220, Brazil.

出版信息

Curr Diab Rep. 2019 Jan 14;19(1):1. doi: 10.1007/s11892-019-1121-x.

DOI:10.1007/s11892-019-1121-x
PMID:30637535
Abstract

PURPOSE OF REVIEW

Breastfeeding has short- and long-term benefits for child health. In this systematic review, we updated a review on the association between breastfeeding and type 2 diabetes.

RECENT FINDINGS

A meta-analysis published in 2015 reported that breastfeeding protects against type 2 diabetes (pooled odds ratio, 0.65 (95% confidence interval, 0.48; 0.86)). In the present update, we identified three recently published studies. An internet-based study reported that at a mean age of 25.6 years, exclusive breastfeeding in the first 6 months protected against type 2 diabetes (odds ratio, 0.63 (95% confidence interval, 0.41; 0.95)). In a retrospective cohort, those subjects who had been breastfed before hospital discharge were less likely of presenting diabetes (odds ratio, 0.83 (95% confidence interval, 0.69; 0.99)). In a case-control study, the odds of type 2 diabetes in adolescents was lower for those exclusively breastfed at hospital discharge (odds ratio, 0.52 (95% confidence interval, 0.36; 0.74)). In the meta-analysis, the pooled odds ratio was 0.67 (95% confidence interval, 0.56; 0.80). The updated systematic review and meta-analysis suggests that breastfeeding protects from type 2 diabetes.

摘要

目的综述

母乳喂养对儿童健康具有短期和长期益处。在本次系统综述中,我们更新了一篇关于母乳喂养与 2 型糖尿病之间关联的综述。

最新发现

2015 年发表的一项荟萃分析报告称,母乳喂养可预防 2 型糖尿病(汇总优势比,0.65(95%置信区间,0.48;0.86))。在本次更新中,我们发现了三项最近发表的研究。一项基于互联网的研究报告称,在平均 25.6 岁时,前 6 个月的纯母乳喂养可预防 2 型糖尿病(比值比,0.63(95%置信区间,0.41;0.95))。在回顾性队列研究中,那些在出院前接受过母乳喂养的受试者发生糖尿病的可能性较低(比值比,0.83(95%置信区间,0.69;0.99))。在一项病例对照研究中,出院时纯母乳喂养的青少年患 2 型糖尿病的几率较低(比值比,0.52(95%置信区间,0.36;0.74))。在荟萃分析中,汇总优势比为 0.67(95%置信区间,0.56;0.80)。本次更新的系统综述和荟萃分析表明,母乳喂养可预防 2 型糖尿病。

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本文引用的文献

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Economic impact of breast-feeding-associated improvements of childhood cognitive development, based on data from the ALSPAC.基于 ALSPAC 数据的母乳喂养对儿童认知发育改善的经济影响。
Br J Nutr. 2019 Sep;122(s1):S16-S21. doi: 10.1017/S0007114515001233. Epub 2016 Jan 22.
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Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up.母乳喂养可减轻与FTO基因相关的肥胖:一项长达30年随访的出生队列研究。
Sci Rep. 2018 Feb 7;8(1):2530. doi: 10.1038/s41598-018-20939-4.
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Prenatal, Obstetric and Perinatal Factors Associated With the Development of Childhood-Onset Type 2 Diabetes.
母乳喂养与配方奶喂养预防糖尿病的分子机制:牛奶对干细胞Wnt信号传导影响的新见解
Front Nutr. 2025 Jul 29;12:1652297. doi: 10.3389/fnut.2025.1652297. eCollection 2025.
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Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life.母乳喂养、遗传易感性与后代成年后患2型糖尿病的关系。
Obesity (Silver Spring). 2025 Sep;33(9):1802-1809. doi: 10.1002/oby.24344. Epub 2025 Jul 23.
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Co-creating and Mapping an Exclusive Breastfeeding Framework among Latino Populations in the United States: An Integrated Framework Adaptation Process and Scoping Review.在美国拉丁裔人群中共同创建和绘制独家母乳喂养框架:一个综合框架适应过程和范围审查。
Adv Nutr. 2025 Jul 19;16(9):100483. doi: 10.1016/j.advnut.2025.100483.
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Healthcare providers insights on the Baby-Friendly Hospital Initiative: A cross-sectional study in Qatar.医疗服务提供者对爱婴医院倡议的见解:卡塔尔的一项横断面研究。
Eur J Midwifery. 2025 Jun 12;9. doi: 10.18332/ejm/203687. eCollection 2025.
7
Relationship Between Perceived Stress, Midwife Support and Exclusive Breastfeeding Among Polish Mothers.波兰母亲的感知压力、助产士支持与纯母乳喂养之间的关系
Nutrients. 2025 May 2;17(9):1573. doi: 10.3390/nu17091573.
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Front Public Health. 2025 Apr 24;13:1585347. doi: 10.3389/fpubh.2025.1585347. eCollection 2025.
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与儿童期 2 型糖尿病发生相关的产前、产科和围产期因素。
Can J Diabetes. 2018 Feb;42(1):71-77. doi: 10.1016/j.jcjd.2017.04.003. Epub 2017 Jun 2.
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Breastfeeding Initiation Associated With Reduced Incidence of Diabetes in Mothers and Offspring.母乳喂养与降低母亲和后代患糖尿病的发病率相关。
Obstet Gynecol. 2016 Nov;128(5):1095-1104. doi: 10.1097/AOG.0000000000001689.
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The role of infant nutrition in the global epidemic of non-communicable disease.婴儿营养在非传染性疾病全球流行中的作用。
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Acta Paediatr. 2015 Dec;104(467):30-7. doi: 10.1111/apa.13133.
9
Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil.母乳喂养与 30 岁时的智力、教育程度和收入的关系:来自巴西的前瞻性出生队列研究。
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Mediation analysis in epidemiology: methods, interpretation and bias.流行病学中的中介分析:方法、解释和偏倚。
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