钙黏蛋白 23 作为同亲性细胞-细胞黏附介质的前景。

The Prospects of Cadherin-23 as a Mediator of Homophilic Cell-Cell Adhesion.

机构信息

Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India.

Centre for Protein Science Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India.

出版信息

Adv Exp Med Biol. 2018;1112:99-105. doi: 10.1007/978-981-13-3065-0_8.

DOI:10.1007/978-981-13-3065-0_8

PMID:30637693

Abstract

Cadherins (calcium-dependent adhesion proteins) constitute a family of cell surface proteins that mediate cell-cell adhesion and actively participate in tissue morphogenesis and in mediating tissue integrity. The ecto-domains of cadherins from opposing cell surfaces interact with each other to form the load-bearing trans-dimers and mechanically hold cells together. The "classical" cadherins and desmosomes that form separate groups in cadherin superfamily are mostly explored for their roles in cell-cell adhesion. However, majority of cadherins in cells belong to "nonclassical" group which is poorly explored in the context of their cell-binding properties. This review focuses on the role of "nonclassical" cadherin, cadherin-23, in cell-cell adhesion. Overall, this review highlights the need for further investigations on the role of "nonclassical" cadherin-23 in cell-cell adhesion.

摘要

钙黏蛋白（钙依赖性黏附蛋白）构成了细胞表面蛋白家族，介导细胞-细胞黏附，并积极参与组织形态发生和组织完整性的维持。来自相对细胞表面的钙黏蛋白的外结构域相互作用，形成承载负荷的跨二聚体，并机械地将细胞保持在一起。钙黏蛋白超家族中的“经典”钙黏蛋白和桥粒大多因其在细胞-细胞黏附中的作用而被探索。然而，细胞中大多数钙黏蛋白属于“非经典”组，其细胞结合特性研究甚少。这篇综述主要关注非经典钙黏蛋白 cadherin-23 在细胞-细胞黏附中的作用。总的来说，这篇综述强调了进一步研究非经典 cadherin-23 在细胞-细胞黏附中作用的必要性。