Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India.
Adv Exp Med Biol. 2018;1112:107-138. doi: 10.1007/978-981-13-3065-0_9.
This article begins with a general review of cell adhesion molecules (CAMs) and narrows the focus down progressively to the cadherins (calcium binding-dependent CAMs), classifications of subfamilies of the cadherins, type I (E- and N-) cadherins, evolutionary relationships amongst cadherins, structural-mechanical and functional consequences of calcium binding to the cadherins, differential molecular interactions involving the extracellular (ecto) and intracellular (cytoplasmic) domains of the cadherins, multiple adherence-related homophilic and heterophilic interactions and associated functions of E- and N-cadherin in organismal development and disease and cadherin trafficking and membrane rafts. It ends by summarizing multiple perspectives and hypotheses concerning different aspects of cadherin structure, stability and function.
本文首先对细胞黏附分子（CAMs）进行了综述，然后逐步将重点缩小到钙黏蛋白（依赖钙结合的 CAMs），钙黏蛋白亚家族的分类，I 型（E-和 N-）钙黏蛋白，钙黏蛋白之间的进化关系，钙结合对钙黏蛋白的结构-力学和功能后果，涉及钙黏蛋白细胞外（ecto）和细胞内（细胞质）结构域的分子相互作用，E-和 N-钙黏蛋白在机体发育和疾病中的多种与黏附相关的同种型和异源型相互作用及其相关功能，以及钙黏蛋白运输和膜筏。最后，本文总结了关于钙黏蛋白结构、稳定性和功能不同方面的多种观点和假设。
