Lewis R R, Padayachee T S, Ariyanayagam R P, Gosling R G
Department of Geriatric and General Medicine, Guy's Hospital, London, UK.
J Hypertens Suppl. 1988 Nov;6(1):S33-6.
Doppler-shifted ultrasound was used as a non-invasive test to determine the presence of severe (pressure dropping) internal carotid lesions in two groups of elderly patients. Group 1 consisted of 150 hypertensive patients; these were subdivided into 77 who had had no cerebrovascular incidents (mean age 75 years, range 65-97) and 73 who had previously suffered a stroke (mean age 75 years, range 65-91). Group 2 consisted of 44 normotensive asymptomatic elderly volunteers (mean age 76 years, range 68-90). In the hypertensive patients (group 1), severe disease was detected in the non-stroke patients in 15 (10%) of the internal carotid arteries (14% of the patients), and in the stroke patients in 23 (16%) of the internal carotid arteries (23% of the patients). None of the normotensive volunteers (group 2) had evidence of severe internal carotid disease. Statistical analysis confirmed a highly significant difference in the prevalence of severe carotid disease between the normotensive and hypertensive subjects. The difference between the non-stroke and stroke hypertensive patients was not statistically significant.
采用多普勒频移超声作为一种非侵入性检测方法，以确定两组老年患者中是否存在严重（压力下降）的颈内动脉病变。第一组由150名高血压患者组成；这些患者又被细分为77名无脑血管事件的患者（平均年龄75岁，范围65 - 97岁）和73名既往有中风史的患者（平均年龄75岁，范围65 - 91岁）。第二组由44名血压正常的无症状老年志愿者组成（平均年龄76岁，范围68 - 90岁）。在高血压患者（第一组）中，未发生中风的患者有15条（10%）颈内动脉检测到严重病变（14%的患者），发生过中风的患者有23条（16%）颈内动脉检测到严重病变（23%的患者）。血压正常的志愿者（第二组）均未发现有严重颈内动脉疾病的证据。统计分析证实，血压正常者与高血压患者之间严重颈动脉疾病的患病率存在极显著差异。未发生中风的高血压患者与发生过中风的高血压患者之间的差异无统计学意义。
