School of Petrochemical Engineering, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, 213164, China.
Org Biomol Chem. 2019 Feb 6;17(6):1336-1350. doi: 10.1039/c8ob03095b.
Supramolecular vesicles have attracted considerable attention due to their advantages of facile construction, high-cargo-loading capacity, and good biocompatibility. Pillar[n]arenes are a unique family of supramolecular macrocycles, exhibiting excellent features and broad applications due to their intrinsic topology and high functionality. In the past decade, the construction of pillar[n]arene-based supramolecular vesicles has been continuously attempted and developed rapidly. In this review, we mainly summarize the significant advancements of such supramolecular vesicles in the last three years. By showing some representative examples, the design strategies, construction methods, and potential applications of these dynamic nanocarriers are discussed in detail. In particular, the responsiveness of such vesicles to various external stimuli and their applications in drug delivery are highlighted. The outstanding performance of pillar[n]arene-based supramolecular vesicles would definitely enrich the family of supramolecular vesicles and promote the development of dynamic supramolecular materials.
超分子囊泡由于其易于构建、高载药能力和良好的生物相容性而受到广泛关注。柱[n]芳烃是一类独特的超分子大环，由于其内在拓扑结构和高功能性，具有优异的性能和广泛的应用。在过去的十年中，基于柱[n]芳烃的超分子囊泡的构建不断被尝试并迅速发展。在这篇综述中，我们主要总结了过去三年中这些超分子囊泡的重要进展。通过展示一些代表性的例子，详细讨论了这些动态纳米载体的设计策略、构建方法和潜在应用。特别是，强调了这些囊泡对各种外部刺激的响应性及其在药物传递中的应用。基于柱[n]芳烃的超分子囊泡的卓越性能必将丰富超分子囊泡家族，并促进动态超分子材料的发展。
