Gomez-Figueroa E, Peiro-Osuna R P, Reyes-Moreno I, Hernandez-Hernandez A, Gutierrez-Aceves A, Santos-Zambrano J, Guerrero-Juarez V, Lopez-Martinez M, Castro-Martinez E, Gonzalez-Aguilar A
Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico DF, Mexico.
American British Cowdray Medical Center (ABC), Mexico DF, Mexico.
Rev Neurol. 2019 Jan 16;68(2):59-65.
Primary lymphoma of the central nervous system is a variety of non-Hodgkin's lymphoma that accounts for 4-5% of intracranial tumours and 5% of all lymphomas. It has its origin in the brain, the eyes, the leptomeninges and the spinal cord with no systemic evidence of lymphomatoid activity; the subtype of lymphoma is predominantly of B-type cells.
We conducted a descriptive study of the patients diagnosed with primary brain lymphoma who were attended to at third-level centres in Mexico between the years 1980 and 2016. Patients who had been screened for systemic lymphoma were included. The results were analysed by means of simple frequencies, and disease-free and overall survival time was analysed by Kaplan-Meier curves; the differences among curves were analysed by means of log rank.
Of a total of 215 patients, there were only 74 cases. By sex, 45% were females and 55% were males. Regarding age, 36.7% were over 60 years old. The most frequent clinical manifestations were motor loss (60%) and cognitive disorders (52%). Most patients received some form of chemotherapy (89%). The only significant factor for radiological response and clinical prognosis was the combined use of radiochemotherapy (p = 0.04493).
Lymphoma is a tumorous condition with a high clinicoradiological response to treatment, although the response is not long-lasting. Its early identification and multidisciplinary management are essential for a more favourable prognosis in these patients.
原发性中枢神经系统淋巴瘤是一种非霍奇金淋巴瘤，占颅内肿瘤的4 - 5%，占所有淋巴瘤的5%。它起源于脑、眼、软脑膜和脊髓，无淋巴瘤样活动的全身证据；淋巴瘤亚型主要为B细胞型。
我们对1980年至2016年间在墨西哥三级中心就诊的原发性脑淋巴瘤患者进行了描述性研究。纳入了已筛查系统性淋巴瘤的患者。结果通过简单频率进行分析，无病生存期和总生存期通过Kaplan-Meier曲线进行分析；曲线间差异通过对数秩检验进行分析。
在总共215例患者中，仅有74例。按性别划分，45%为女性，55%为男性。按年龄划分，36.7%的患者年龄超过60岁。最常见的临床表现是运动功能丧失（60%）和认知障碍（52%）。大多数患者接受了某种形式的化疗（89%）。放射学反应和临床预后的唯一显著因素是放化疗联合使用（p = 0.04493）。
淋巴瘤是一种对治疗有较高临床放射学反应的肿瘤性疾病，尽管反应不持久。早期识别和多学科管理对于这些患者获得更有利的预后至关重要。
