Aki Hilal, Uzunaslan Didem, Saygin Caner, Batur Sebnem, Tuzuner Nukhet, Kafadar Ali, Ongoren Seniz, Oz Buge
Department of Pathology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Int J Clin Exp Pathol. 2013 May 15;6(6):1068-75. Print 2013.
Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, eyes or spinal cord by non-Hodgkin lymphoma. The role of various prognostic markers in predicting adverse outcome is debated.
To investigate the clinical and immunohistochemical findings of immunocompetent PCNSL cases (39 cases) diagnosed at the study center, and evaluate the influence of potential prognostic factors on overall survival (OS) of patients.
Data regarding patient characteristics, neuroimaging, pathological and immunohistochemical features and follow-up were obtained from patient records. The influence of potential prognostic parameters on OS was investigated by log-rank test and Cox regression analysis.
Patients who received combined chemotherapy and radiotherapy had a significantly better OS when compared to chemotherapy alone. Other variables included in this study were not associated with a significant survival advantage.
In this study, we failed to demonstrate a relationship between different clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential prognostic factors.
原发性中枢神经系统淋巴瘤（PCNSL）定义为非霍奇金淋巴瘤累及脑、软脑膜、眼或脊髓。各种预后标志物在预测不良结局中的作用存在争议。
研究在本研究中心诊断的免疫功能正常的PCNSL病例（39例）的临床和免疫组化结果，并评估潜在预后因素对患者总生存期（OS）的影响。
从患者记录中获取有关患者特征、神经影像学、病理和免疫组化特征以及随访的数据。通过对数秩检验和Cox回归分析研究潜在预后参数对OS的影响。
与单纯化疗相比，接受联合化疗和放疗的患者OS明显更好。本研究中纳入的其他变量与显著的生存优势无关。
在本研究中，我们未能证明不同临床病理变量与患者OS之间的关系。需要对大量患者进行前瞻性研究以调查其他潜在预后因素。
